din-1 Daf-12-interacting protein 1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: din-1
Official Full Name: Daf-12-interacting protein 1
Primary source: WormBase:WBGene00008549
Locus tag: CELE_F07A11.6
See related: AllianceGenome:WB:WBGene00008549
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein ubiquitination and ubiquitin-dependent protein catabolic process. Located in nucleus. Is expressed in several structures, including body wall musculature; hermaphrodite distal tip cell; intestine; pharynx; and vulval precursor cell. Human ortholog(s) of this gene implicated in esophagus squamous cell carcinoma. Orthologous to human SPEN (spen family transcriptional repressor). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See din-1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 22

Sequence:: Chromosome: II; NC_003280.10 (11614770..11633609, complement)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

When bound to its ligand, DAF-12 acquires transcriptional activity that directs reproductive development, while unliganded DAF-12 forms a dauer-specifying complex with its interacting protein DIN-1S to regulate the transcription of genes required for dauer development
Title: Developmental and Cell Cycle Quiescence Is Mediated by the Nuclear Hormone Receptor Coregulator DIN-1S in the Caenorhabditis elegans Dauer Larva.
The DIN-1S/DAF-12 complex serves as a molecular switch that implements slow life history alternatives in response to diminished hormonal signals
Title: A novel nuclear receptor/coregulator complex controls C. elegans lipid metabolism, larval development, and aging.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F07A11.6 (e-PCR)
- UniSTS:309572

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in intracellular membrane-bounded organelle	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Daf-12-interacting protein 1

NP_001254306.1

Confirmed by transcript evidence

NP_001254307.1

Confirmed by transcript evidence

NP_001379428.1

Confirmed by transcript evidence

NP_496484.3

Confirmed by transcript evidence

NP_496485.2

Confirmed by transcript evidence

NP_871901.1

Confirmed by transcript evidence

NP_871902.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

11614770..11633609 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_182102.7 → NP_871902.1 Daf-12-interacting protein 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_871902.1

Status: REVIEWED

UniProtKB/Swiss-Prot

G5EGK6

Conserved Domains (1) summary

pfam07744
Location:384 → 498

SPOC; SPOC domain
NM_064083.7 → NP_496484.3 Daf-12-interacting protein 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_496484.3

Status: REVIEWED

UniProtKB/Swiss-Prot

G5EGK6

Conserved Domains (6) summary

PRK01741
Location:1576 → 1765

PRK01741; cell division protein ZipA; Provisional

pfam07744
Location:2028 → 2142

SPOC; SPOC domain

pfam11221
Location:1721 → 1799

Med21; Subunit 21 of Mediator complex

cd16269
Location:1902 → 1928

GBP_C; coiled coil [structural motif]

cl17169
Location:279 → 332

RRM_SF; RNA recognition motif (RRM) superfamily

cl20817
Location:1845 → 1947

GBP_C; Guanylate-binding protein, C-terminal domain
NM_182101.5 → NP_871901.1 Daf-12-interacting protein 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_871901.1

Status: REVIEWED

UniProtKB/Swiss-Prot

G5EGK6

Conserved Domains (5) summary

pfam07744
Location:2209 → 2323

SPOC; SPOC domain

pfam11221
Location:1902 → 1980

Med21; Subunit 21 of Mediator complex

cd16269
Location:2083 → 2109

GBP_C; coiled coil [structural motif]

cl17169
Location:264 → 317

RRM_SF; RNA recognition motif (RRM) superfamily

cl20817
Location:2026 → 2128

GBP_C; Guanylate-binding protein, C-terminal domain
NM_064084.9 → NP_496485.2 Daf-12-interacting protein 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_496485.2

Status: REVIEWED

UniProtKB/Swiss-Prot

E1B6R6, G5EBT0, G5ED50, G5EDA4, G5EEE3, G5EGK6, Q8I124

Conserved Domains (5) summary

pfam07744
Location:2224 → 2338

SPOC; SPOC domain

pfam11221
Location:1917 → 1995

Med21; Subunit 21 of Mediator complex

cd16269
Location:2098 → 2124

GBP_C; coiled coil [structural motif]

cl17169
Location:279 → 332

RRM_SF; RNA recognition motif (RRM) superfamily

cl20817
Location:2041 → 2143

GBP_C; Guanylate-binding protein, C-terminal domain
NM_001393199.1 → NP_001379428.1 Daf-12-interacting protein 1 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (4) summary

TIGR03835
Location:1295 → 1604

termin_org_DnaJ; terminal organelle assembly protein TopJ

pfam05109
Location:443 → 702

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

pfam07744
Location:1910 → 2077

SPOC; SPOC domain

pfam15346
Location:1739 → 1794

ARGLU; Arginine and glutamate-rich 1
NM_001267377.3 → NP_001254306.1 Daf-12-interacting protein 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001254306.1

Status: REVIEWED

UniProtKB/Swiss-Prot

G5EGK6

Conserved Domains (3) summary

pfam07744
Location:1831 → 1945

SPOC; SPOC domain

cd16269
Location:1705 → 1731

GBP_C; coiled coil [structural motif]

cl20817
Location:1648 → 1750

GBP_C; Guanylate-binding protein, C-terminal domain
NM_001267378.3 → NP_001254307.1 Daf-12-interacting protein 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001254307.1

Status: REVIEWED

UniProtKB/Swiss-Prot

G5EGK6

Conserved Domains (1) summary

pfam07744
Location:3 → 117

SPOC; SPOC domain