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    clec-49 C-type lectin domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 180298, updated on 9-Dec-2024

    Summary

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    Official Symbol
    clec-49
    Official Full Name
    C-type lectin domain-containing protein
    Primary source
    WormBase:WBGene00012251
    Locus tag
    CELE_W04E12.6
    See related
    AllianceGenome:WB:WBGene00012251
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable monosaccharide binding activity and signaling receptor activity. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See clec-49 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    4
    Sequence:
    Chromosome: V; NC_003283.11 (19748961..19751226, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Kinesin-associated protein 3-like Neighboring gene LEM domain-containing protein;TPR_REGION domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene C-type lectin domain-containing protein Neighboring gene MFS domain-containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A novel C-type lectin secreted by a tissue-dwelling parasitic nematode. Loukas A, et al. Curr Biol, 1999 Jul 29-Aug 12. PMID 10469567
    2. Genome-wide evaluation of the interplay between Caenorhabditis elegans and Yersinia pseudotuberculosis during in vivo biofilm formation. Joshua GW, et al. Infect Immun, 2015 Jan. PMID 25312958, Free PMC Article
    3. The C-type lectin-like domain containing proteins Clec-39 and Clec-49 are crucial for Caenorhabditis elegans immunity against Serratia marcescens infection. Miltsch SM, et al. Dev Comp Immunol, 2014 Jul. PMID 24534554
    4. Transcriptomics of ivermectin response in Caenorhabditis elegans: Integrating abamectin quantitative trait loci and comparison to the Ivermectin-exposed DA1316 strain. Dube F, et al. PLoS One, 2023. PMID 37141255, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Two c-type lectin-like domain proteins, Clec-39 and Clec-49, are crucial for C. elegans immunity to S. marcescens infection.
      Title: The C-type lectin-like domain containing proteins Clec-39 and Clec-49 are crucial for Caenorhabditis elegans immunity against Serratia marcescens infection.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables monosaccharide binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    C-type lectin domain-containing protein
    NP_507829.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      19748961..19751226 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_075428.5 → NP_507829.1  C-type lectin domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_507829.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9XUL6
      Conserved Domains (1) summary
      smart00034
      Location:31 → 146
      CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
    Nucleotide Protein
    Heading Accession and Version

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