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    unc-105 Degenerin-like protein unc-105 [ Caenorhabditis elegans ]

    Gene ID: 174306, updated on 9-Dec-2024

    Summary

    Official Symbol
    unc-105
    Official Full Name
    Degenerin-like protein unc-105
    Primary source
    WormBase:WBGene00006832
    Locus tag
    CELE_C41C4.5
    See related
    AllianceGenome:WB:WBGene00006832
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables monoatomic ion channel activity. Involved in calcium ion transport; magnesium ion transport; and muscle organ development. Predicted to be located in membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in Liddle syndrome; bronchiectasis 1; bronchiectasis 3; and pseudohypoaldosteronism. Orthologous to human SCNN1B (sodium channel epithelial 1 subunit beta); SCNN1D (sodium channel epithelial 1 subunit delta); and SCNN1G (sodium channel epithelial 1 subunit gamma). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See unc-105 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    16
    Sequence:
    Chromosome: II; NC_003280.10 (8116459..8122914)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene eLRR (extracellular Leucine-Rich Repeat) ONly Neighboring gene Endoribonuclease;Serine/threonine-protein kinase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Ubiquitin-like protease 4

    General gene information

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ligand-gated sodium channel activity  
    enables monoatomic ion channel activity PubMed 
    enables monoatomic ion channel activity  
    enables sodium channel activity  
    Process Evidence Code Pubs
    involved_in calcium ion transport PubMed 
    involved_in cell differentiation  
    involved_in magnesium ion transport PubMed 
    involved_in monoatomic ion transmembrane transport  
    involved_in monoatomic ion transport  
    involved_in muscle organ development  
    involved_in muscle organ development PubMed 
    involved_in sodium ion transmembrane transport  
    involved_in sodium ion transport  
    Component Evidence Code Pubs
    located_in membrane PubMed 
    located_in membrane  
    is_active_in plasma membrane  

    General protein information

    Preferred Names
    Degenerin-like protein unc-105
    NP_001122595.1
    • Confirmed by transcript evidence
    NP_001254139.1
    • Confirmed by transcript evidence
    NP_001364812.1
    • Confirmed by transcript evidence
    NP_001367274.1
    • Confirmed by transcript evidence
    NP_001368112.1
    • Confirmed by transcript evidence
    NP_495702.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      8116459..8122914
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001377828.2 → NP_001364812.1  Degenerin-like protein unc-105 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2FLF9
      Conserved Domains (1) summary
      TIGR00867
      Location:119 → 763
      deg-1; degenerin
    2. NM_001381518.2 → NP_001367274.1  Degenerin-like protein unc-105 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      E5QCG1
      Conserved Domains (1) summary
      TIGR00867
      Location:13 → 657
      deg-1; degenerin
    3. NM_001381517.1 → NP_001368112.1  Degenerin-like protein unc-105 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2FLF8
      Conserved Domains (1) summary
      TIGR00867
      Location:119 → 763
      deg-1; degenerin
    4. NM_001267210.3 → NP_001254139.1  Degenerin-like protein unc-105 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254139.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2FLG0
      Conserved Domains (2) summary
      TIGR00867
      Location:119 → 763
      deg-1; degenerin
      cl02990
      Location:119 → 764
      ASC; Amiloride-sensitive sodium channel
    5. NM_063301.6 → NP_495702.1  Degenerin-like protein unc-105 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495702.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q09274
      Conserved Domains (2) summary
      TIGR00867
      Location:33 → 677
      deg-1; degenerin
      cl02990
      Location:33 → 704
      ASC; Amiloride-sensitive sodium channel
    6. NM_001129123.3 → NP_001122595.1  Degenerin-like protein unc-105 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001122595.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A3FPK3, Q09274
      Conserved Domains (2) summary
      TIGR00867
      Location:71 → 715
      deg-1; degenerin
      cl02990
      Location:71 → 742
      ASC; Amiloride-sensitive sodium channel
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