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    rpn-2 26S proteasome non-ATPase regulatory subunit 1 [ Caenorhabditis elegans ]

    Gene ID: 175877, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rpn-2
    Official Full Name
    26S proteasome non-ATPase regulatory subunit 1
    Primary source
    WormBase:WBGene00004459
    Locus tag
    CELE_C23G10.4
    See related
    AllianceGenome:WB:WBGene00004459
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables protein kinase C binding activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Located in several cellular components, including cell cortex; mitotic spindle; and nuclear membrane. Is expressed in intestine. Orthologous to human PSMD1 (proteasome 26S subunit, non-ATPase 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See rpn-2 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    7
    Sequence:
    Chromosome: III; NC_003281.10 (6199184..6202594)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene putative tRNA (uracil-O(2)-)-methyltransferase Neighboring gene NADAR domain-containing protein Neighboring gene Small ribosomal subunit protein uS3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Symmetrically dividing cell specific division axes alteration observed in proteasome depleted C. elegans embryo. Sugiyama Y, et al. Mech Dev, 2008 Aug. PMID 18502617
    2. A bacterial metabolite induces glutathione-tractable proteostatic damage, proteasomal disturbances, and PINK1-dependent autophagy in C. elegans. Martinez BA, et al. Cell Death Dis, 2015 Oct 15. PMID 26469957, Free PMC Article
    3. Exploring transcriptional conservation between Ancylostoma caninum and Haemonchus contortus by oligonucleotide microarray and bioinformatic analyses. Cantacessi C, et al. Mol Cell Probes, 2009 Feb. PMID 18977290
    4. The WD40 repeat protein WDR-23 functions with the CUL4/DDB1 ubiquitin ligase to regulate nuclear abundance and activity of SKN-1 in Caenorhabditis elegans. Choe KP, et al. Mol Cell Biol, 2009 May. PMID 19273594, Free PMC Article
    5. Proteasome activity contributes to pro-survival response upon mild mitochondrial stress in Caenorhabditis elegans. Sladowska M, et al. PLoS Biol, 2021 Jul. PMID 34252079, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables enzyme regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase C binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitotic spindle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of proteasome complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of proteasome regulatory particle, base subcomplex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in proteasome storage granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    26S proteasome non-ATPase regulatory subunit 1
    NP_001379706.1
    • Confirmed by transcript evidence
    NP_498346.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      6199184..6202594
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_065945.7 → NP_498346.2  26S proteasome non-ATPase regulatory subunit 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498346.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q18114, Q18115
      Conserved Domains (3) summary
      COG5116
      Location:38 → 959
      RPN2; 26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]
      pfam01851
      Location:630 → 663
      PC_rep; Proteasome/cyclosome repeat
      sd00044
      Location:577 → 606
      HEAT; HEAT repeat [structural motif]

    2. NM_001392118.1 → NP_001379706.1  26S proteasome non-ATPase regulatory subunit 1 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (2) summary
      COG5116
      Location:38 → 833
      RPN2; 26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]
      sd00044
      Location:577 → 606
      HEAT; HEAT repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q18115.4

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