mgl-1 G-protein coupled receptors family 3 profile domain-containing protein;putative metabotropic glutamate receptor mgl-1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: mgl-1
Official Full Name: G-protein coupled receptors family 3 profile domain-containing protein;putative metabotropic glutamate receptor mgl-1
Primary source: WormBase:WBGene00003232
Locus tag: CELE_ZC506.4
See related: AllianceGenome:WB:WBGene00003232
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable group II metabotropic glutamate receptor activity. Involved in positive regulation of lipid storage. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in nerve ring; neurons; and pharyngeal nervous system. Used to study Alzheimer's disease. Human ortholog(s) of this gene implicated in alcohol dependence; attention deficit hyperactivity disorder; autistic disorder; congenital stationary night blindness 1B; and schizophrenia. Orthologous to several human genes including GRM3 (glutamate metabotropic receptor 3). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See mgl-1 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 21

Sequence:: Chromosome: X; NC_003284.9 (9968517..9976306, complement)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MGL-1 is the molecular driver underlying the translation of starvation signals to reproduction plasticity in an AIY neuron-specific manner.
Title: MGL-1 on AIY neurons translates starvation to reproductive plasticity via neuropeptide signaling in Caenorhabditis elegans.
Local food search is triggered by two parallel groups of chemosensory and mechanosensory glutamatergic neurons that detect food-related cues. Each group of sensory neurons suppresses distinct integrating neurons through a G protein-coupled metabotropic glutamate receptor, MGL-1, to release local search.
Title: Parallel Multimodal Circuits Control an Innate Foraging Behavior.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ZC506.4 (e-PCR)
- UniSTS:310385

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables group II metabotropic glutamate receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in G protein-coupled glutamate receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of lipid storage	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of synaptic transmission, glutamatergic	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: G-protein coupled receptors family 3 profile domain-containing protein;putative metabotropic glutamate receptor mgl-1

NP_001123193.2

Confirmed by transcript evidence

NP_001300387.1

Partially confirmed by transcript evidence

NP_001300388.1

Confirmed by transcript evidence

NP_509674.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

9968517..9976306 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_077273.4 → NP_509674.2 putative metabotropic glutamate receptor mgl-1 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q09630

Conserved Domains (4) summary

cd06362
Location:51 → 544

PBP1_mGluR; Ligand binding domain of the metabotropic glutamate receptors (mGluR)

pfam00003
Location:643 → 876

7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR

pfam01094
Location:82 → 505

ANF_receptor; Receptor family ligand binding region

pfam07562
Location:558 → 606

NCD3G; Nine Cysteines Domain of family 3 GPCR
NM_001313458.3 → NP_001300387.1 G-protein coupled receptors family 3 profile domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q09630

UniProtKB/TrEMBL

A0A0K3ASV1

Conserved Domains (3) summary

cd15934
Location:633 → 882

7tmC_mGluRs_group2_3; metabotropic glutamate receptors in group 2 and 3, member of the class C family of seven-transmembrane G protein-coupled receptors

pfam07562
Location:560 → 610

NCD3G; Nine Cysteines Domain of family 3 GPCR

cd06362
Location:54 → 547

PBP1_mGluR; ligand binding domain of metabotropic glutamate receptors (mGluR)
NM_001129721.4 → NP_001123193.2 G-protein coupled receptors family 3 profile domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q09630

UniProtKB/TrEMBL

A3FPK2

Conserved Domains (3) summary

cd15934
Location:619 → 868

7tmC_mGluRs_group2_3; metabotropic glutamate receptors in group 2 and 3, member of the class C family of seven-transmembrane G protein-coupled receptors

pfam07562
Location:546 → 596

NCD3G; Nine Cysteines Domain of family 3 GPCR

cd06362
Location:40 → 533

PBP1_mGluR; ligand binding domain of metabotropic glutamate receptors (mGluR)
NM_001313459.3 → NP_001300388.1 G-protein coupled receptors family 3 profile domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q09630

UniProtKB/TrEMBL

A0A0K3AWH7

Conserved Domains (3) summary

cd15934
Location:544 → 793

7tmC_mGluRs_group2_3; metabotropic glutamate receptors in group 2 and 3, member of the class C family of seven-transmembrane G protein-coupled receptors

pfam07562
Location:471 → 521

NCD3G; Nine Cysteines Domain of family 3 GPCR

cd06362
Location:1 → 458

PBP1_mGluR; ligand binding domain of metabotropic glutamate receptors (mGluR)