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    let-4 Leucine-rich repeat-containing protein let-4 [ Caenorhabditis elegans ]

    Gene ID: 181554, updated on 9-Dec-2024

    Summary

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    Official Symbol
    let-4
    Official Full Name
    Leucine-rich repeat-containing protein let-4
    Primary source
    WormBase:WBGene00002282
    Locus tag
    CELE_C44H4.2
    See related
    AllianceGenome:WB:WBGene00002282
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in several processes, including epithelial cell development; nematode larval development; and positive regulation of membrane permeability. Located in apical part of cell. Is expressed in excretory system; hypodermis; rectal epithelial cell; and vulva. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See let-4 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    9
    Sequence:
    Chromosome: X; NC_003284.9 (14577935..14580923)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Chorein N-terminal domain-containing protein Neighboring gene LRRCT domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Leucine-rich repeat-containing protein let-4 Neighboring gene ncRNA Neighboring gene TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Integrity of Narrow Epithelial Tubes in the C. elegans Excretory System Requires a Transient Luminal Matrix. Gill HK, et al. PLoS Genet, 2016 Aug. PMID 27482894, Free PMC Article
    2. Suppression and function of X-linked lethal and sterile mutations in Caenorhabditis elegans. Meneely PM, et al. Genetics, 1981 Jan. PMID 7196363, Free PMC Article
    3. Lethals, steriles and deficiencies in a region of the X chromosome of Caenorhabditis elegans. Meneely PM, et al. Genetics, 1979 May. PMID 574105, Free PMC Article
    4. The apical ECM preserves embryonic integrity and distributes mechanical stress during morphogenesis. Vuong-Brender TTK, et al. Development, 2017 Dec 1. PMID 28526752, Free PMC Article
    5. Extracellular leucine-rich repeat proteins are required to organize the apical extracellular matrix and maintain epithelial junction integrity in C. elegans. Mancuso VP, et al. Development, 2012 Mar. PMID 22278925, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in cell development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in embryo development ending in birth or egg hatching IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in embryo development ending in birth or egg hatching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in epithelial cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nematode larval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of membrane permeability IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of tube size IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apical part of cell IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Leucine-rich repeat-containing protein let-4
    NP_510425.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      14577935..14580923
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078024.5 → NP_510425.2  Leucine-rich repeat-containing protein let-4 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_510425.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q93373
      Conserved Domains (3) summary
      cd00116
      Location:250 → 411
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:88 → 111
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:256 → 316
      LRR_8; Leucine rich repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q93373.2

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