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    tub-1 Tubby protein homolog 1 [ Caenorhabditis elegans ]

    Gene ID: 174312, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tub-1
    Official Full Name
    Tubby protein homolog 1
    Primary source
    WormBase:WBGene00006655
    Locus tag
    CELE_F10B5.4
    See related
    AllianceGenome:WB:WBGene00006655
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in positive regulation of neurogenesis and receptor localization to non-motile cilium. Located in cytoplasm; non-motile cilium; and periciliary membrane compartment. Is expressed in neurons. Used to study obesity. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 15; retinitis pigmentosa; and retinitis pigmentosa 14. Orthologous to human TUB (TUB bipartite transcription factor); TULP1 (TUB like protein 1); and TULP3 (TUB like protein 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See tub-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    6
    Sequence:
    Chromosome: II; NC_003280.10 (8154096..8156945, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Large ribosomal subunit protein uL16 Neighboring gene Protein AAR2 homolog Neighboring gene BTB domain-containing protein Neighboring gene Transmembrane protein 138 Neighboring gene Putative pachytene checkpoint protein 2 Neighboring gene Cell division cycle protein 16 homolog

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The use of FUdR can cause prolonged longevity in mutant nematodes. Aitlhadj L, et al. Mech Ageing Dev, 2010 May. PMID 20236608
    2. Genetic and molecular analysis of a Caenorhabditis elegans beta-tubulin that conveys benzimidazole sensitivity. Driscoll M, et al. J Cell Biol, 1989 Dec. PMID 2592410, Free PMC Article
    3. Characterization of taurine as anti-obesity agent in C. elegans. Kim HM, et al. J Biomed Sci, 2010 Aug 24. PMID 20804609, Free PMC Article
    4. C. elegans tubby regulates life span and fat storage by two independent mechanisms. Mukhopadhyay A, et al. Cell Metab, 2005 Jul. PMID 16054097
    5. FTIR imaging detects diet and genotype-dependent chemical composition changes in wild type and mutant C. elegans strains. Bouyanfif A, et al. Analyst, 2017 Dec 4. PMID 29139484

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. We show that compromised sensory signaling alters cilia membrane phosphoinositide composition via TUB-1-dependent trafficking of a PIP5 kinase. TUB-1 regulates localization of this lipid kinase at the cilia base in part via localization of the AP-2 adaptor complex subunit DPY-23.
      Title: The Caenorhabditis elegans Tubby homolog dynamically modulates olfactory cilia membrane morphogenesis and phospholipid composition.
    2. Results propose that TUB-1 controls receptor or sensory molecule degradation in neurons by regulating a RAB-7-mediated endocytic pathway.
      Title: An endocytic pathway as a target of tubby for regulation of fat storage.
    3. we define a role for tub-1 in regulation of life span and show that tub-1 regulates life span and fat storage by two independent mechanisms.
      Title: C. elegans tubby regulates life span and fat storage by two independent mechanisms.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in chemotaxis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of neurogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to non-motile cilium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in receptor localization to non-motile cilium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cilium IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in non-motile cilium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in periciliary membrane compartment IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Tubby protein homolog 1
    NP_495710.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      8154096..8156945 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_063309.5 → NP_495710.1  Tubby protein homolog 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495710.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q09306, Q9UB22
      Conserved Domains (1) summary
      pfam01167
      Location:174 → 419
      Tub; Tub family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q09306.3

    Gene LinkOut

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