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    F07A11.4 Ubiquitin carboxyl-terminal hydrolase;ubiquitinyl hydrolase 1 [ Caenorhabditis elegans ]

    Gene ID: 174780, updated on 9-Dec-2024

    Summary

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    Official Symbol
    F07A11.4
    Official Full Name
    Ubiquitin carboxyl-terminal hydrolase;ubiquitinyl hydrolase 1
    Primary source
    WormBase:WBGene00008547
    Locus tag
    CELE_F07A11.4
    See related
    AllianceGenome:WB:WBGene00008547
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable cysteine-type deubiquitinase activity and metal ion binding activity. Predicted to be involved in ERAD pathway and regulation of protein stability. Is expressed in body wall musculature; pharynx; and reproductive system. Orthologous to human USP19 (ubiquitin specific peptidase 19). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See F07A11.4 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    8
    Sequence:
    Chromosome: II; NC_003280.10 (11603956..11611549)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Ribokinase Neighboring gene Daf-12-interacting protein 1 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A modified TurboID approach identifies tissue-specific centriolar components in C. elegans. Holzer E, et al. PLoS Genet, 2022 Apr. PMID 35442950, Free PMC Article
    2. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein deubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of protein stability IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Ubiquitin carboxyl-terminal hydrolase;ubiquitinyl hydrolase 1
    NP_001254305.1
    • Confirmed by transcript evidence
    NP_001364591.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      11603956..11611549
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001377876.3 → NP_001364591.1  ubiquitinyl hydrolase 1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q19132
      Conserved Domains (2) summary
      COG5560
      Location:401 → 1110
      UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
      pfam01753
      Location:716 → 756
      zf-MYND; MYND finger

    2. NM_001267376.3 → NP_001254305.1  Ubiquitin carboxyl-terminal hydrolase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254305.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      I2HA92
      Conserved Domains (3) summary
      cl02553
      Location:767 → 921
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam01753
      Location:529 → 569
      zf-MYND; MYND finger
      pfam14533
      Location:445 → 522
      USP7_C2; Ubiquitin-specific protease C-terminal
    Nucleotide Protein
    Heading Accession and Version

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