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    mec-5 Uncharacterized protein [ Caenorhabditis elegans ]

    Gene ID: 181678, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mec-5
    Official Full Name
    Uncharacterized protein
    Primary source
    WormBase:WBGene00003169
    Locus tag
    CELE_E03G2.3
    See related
    AllianceGenome:WB:WBGene00003169
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be an extracellular matrix structural constituent. Involved in several processes, including detection of mechanical stimulus involved in sensory perception of touch; positive regulation of detection of mechanical stimulus involved in sensory perception of touch; and positive regulation of mechanosensory behavior. Located in extracellular matrix. Is expressed in several structures, including hypodermis; intestine; muscle cell; nervous system; and tail. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See mec-5 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    7
    Sequence:
    Chromosome: X; NC_003284.9 (15944009..15948952)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene ABC transmembrane type-1 domain-containing protein Neighboring gene Nematode cuticle collagen N-terminal domain-containing protein Neighboring gene Neuropeptide-Like Protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Extracellular proteins organize the mechanosensory channel complex in C. elegans touch receptor neurons. Emtage L, et al. Neuron, 2004 Dec 2. PMID 15572111
    2. Extracellular proteins needed for C. elegans mechanosensation. Du H, et al. Neuron, 1996 Jan. PMID 8562083
    3. Nanoscale organization of the MEC-4 DEG/ENaC sensory mechanotransduction channel in Caenorhabditis elegans touch receptor neurons. Cueva JG, et al. J Neurosci, 2007 Dec 19. PMID 18094248, Free PMC Article
    4. Neuron-epidermal attachment protects hyper-fragile axons from mechanical strain. Bonacossa-Pereira I, et al. Cell Rep, 2022 Mar 8. PMID 35263583
    5. Touch-induced mechanical strain in somatosensory neurons is independent of extracellular matrix mutations in Caenorhabditis elegans. Nekimken AL, et al. Mol Biol Cell, 2020 Jul 21. PMID 32579427, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables extracellular matrix structural constituent ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in detection of mechanical stimulus involved in sensory perception of touch IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in detection of mechanical stimulus involved in sensory perception of touch IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mechanosensory behavior IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in mechanosensory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of detection of mechanical stimulus involved in sensory perception of touch IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of mechanosensory behavior IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in response to mechanical stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Uncharacterized protein
    NP_741941.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      15944009..15948952
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_171808.6 → NP_741941.1  Uncharacterized protein CELE_E03G2.3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741941.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EFQ9
      Conserved Domains (1) summary
      pfam01391
      Location:136 → 194
      Collagen; Collagen triple helix repeat (20 copies)
    Nucleotide Protein
    Heading Accession and Version

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