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    ife-3 Eukaryotic translation initiation factor 4E-3 [ Caenorhabditis elegans ]

    Gene ID: 178536, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ife-3
    Official Full Name
    Eukaryotic translation initiation factor 4E-3
    Primary source
    WormBase:WBGene00002061
    Locus tag
    CELE_B0348.6
    See related
    AllianceGenome:WB:WBGene00002061
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables RNA 7-methylguanosine cap binding activity. Involved in embryo development. Predicted to be located in perinuclear region of cytoplasm. Predicted to be part of eukaryotic translation initiation factor 4F complex. Is expressed in Z2; Z3; germ line; gonad; and oocyte. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human EIF4E (eukaryotic translation initiation factor 4E) and EIF4E1B (eukaryotic translation initiation factor 4E family member 1B). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ife-3 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    4
    Sequence:
    Chromosome: V; NC_003283.11 (6584..7828, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Intrinsically Disordered Protein, expressed in Pharynx Neighboring gene Secreted protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural basis for nematode eIF4E binding an m(2,2,7)G-Cap and its implications for translation initiation. Liu W, et al. Nucleic Acids Res, 2011 Nov 1. PMID 21965542, Free PMC Article
    2. The nematode eukaryotic translation initiation factor 4E/G complex works with a trans-spliced leader stem-loop to enable efficient translation of trimethylguanosine-capped RNAs. Wallace A, et al. Mol Cell Biol, 2010 Apr. PMID 20154140, Free PMC Article
    3. The endogenous mex-3 3´UTR is required for germline repression and contributes to optimal fecundity in C. elegans. Albarqi MMY, et al. PLoS Genet, 2021 Aug. PMID 34424904, Free PMC Article
    4. Dynamical insight into Caenorhabditis elegans eIF4E recognition specificity for mono-and trimethylated structures of mRNA 5' cap. Ruszczyńska-Bartnik K, et al. J Mol Model, 2011 Apr. PMID 20535623, Free PMC Article
    5. Multiple isoforms of eukaryotic protein synthesis initiation factor 4E in Caenorhabditis elegans can distinguish between mono- and trimethylated mRNA cap structures. Jankowska-Anyszka M, et al. J Biol Chem, 1998 Apr 24. PMID 9553113

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data suggest that mRNA 5' untranslated regions affect translation initiation through interaction with eIF4E/G in nematodes and raise the issue of whether eIF4E/G-RNA interactions play a role in the translation of other eukaryotic mRNAs.
      Title: The nematode eukaryotic translation initiation factor 4E/G complex works with a trans-spliced leader stem-loop to enable efficient translation of trimethylguanosine-capped RNAs.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA 7-methylguanosine cap binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA 7-methylguanosine cap binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA 7-methylguanosine cap binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    NOT involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in embryo development ending in birth or egg hatching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulatory ncRNA-mediated gene silencing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translational initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of eukaryotic translation initiation factor 4F complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Eukaryotic translation initiation factor 4E-3
    NP_503123.1
    • Confirmed by transcript evidence
    NP_503124.1
    • Confirmed by transcript evidence
    NP_741502.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      6584..7828 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_171920.6 → NP_741502.1  Eukaryotic translation initiation factor 4E-3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741502.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O61955
      Conserved Domains (1) summary
      pfam01652
      Location:36 → 194
      IF4E; Eukaryotic initiation factor 4E

    2. NM_070722.6 → NP_503123.1  Eukaryotic translation initiation factor 4E-3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_503123.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O61955, Q8MNX5, Q95X31
      Conserved Domains (1) summary
      pfam01652
      Location:36 → 195
      IF4E; Eukaryotic initiation factor 4E

    3. NM_070723.8 → NP_503124.1  Eukaryotic translation initiation factor 4E-3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_503124.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O61955
      Conserved Domains (1) summary
      pfam01652
      Location:36 → 192
      IF4E; Eukaryotic initiation factor 4E
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O61955.2

    Gene LinkOut

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