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    gnrr-1 G-protein coupled receptors family 1 profile domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 186230, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gnrr-1
    Official Full Name
    G-protein coupled receptors family 1 profile domain-containing protein
    Primary source
    WormBase:WBGene00018798
    Locus tag
    CELE_F54D7.3
    See related
    AllianceGenome:WB:WBGene00018798
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway and cellular response to hormone stimulus. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in intestine; neurons; oocyte; pharynx; and sperm. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 7 with or without anosmia. Orthologous to several human genes including GNRHR (gonadotropin releasing hormone receptor). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See gnrr-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    6
    Sequence:
    Chromosome: I; NC_003279.8 (4799981..4804396)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L41 Neighboring gene Zwei Ig domain protein zig-7 Neighboring gene EthanolaminePhosphoTransferase 1 homolog Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene Twenty One u-rna (21U-RNA) biogenesis Fouled Up

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of a gonadotropin-releasing hormone receptor orthologue in Caenorhabditis elegans. Vadakkadath Meethal S, et al. BMC Evol Biol, 2006 Nov 29. PMID 17134503, Free PMC Article
    2. A forward genetic approach for analyzing the mechanism of resistance to the anti-cancer drug, 5-fluorouracil, using Caenorhabditis elegans. Kim S, et al. Mol Cells, 2008 Feb 29. PMID 18319623
    3. Cannabinoids activate the insulin pathway to modulate mobilization of cholesterol in C. elegans. Hernandez-Cravero B, et al. PLoS Genet, 2022 Nov. PMID 36346800, Free PMC Article
    4. Innate immunity in Caenorhabditis elegans is regulated by neurons expressing NPR-1/GPCR. Styer KL, et al. Science, 2008 Oct 17. PMID 18801967, Free PMC Article
    5. The neuropeptidergic connectome of C. elegans. Ripoll-Sánchez L, et al. Neuron, 2023 Nov 15. PMID 37935195, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables vasopressin receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to hormone stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    G-protein coupled receptors family 1 profile domain-containing protein
    NP_001249720.1
    • Confirmed by transcript evidence
    NP_001249721.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      4799981..4804396
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001262791.3 → NP_001249720.1  G-protein coupled receptors family 1 profile domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001249720.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O44731
      Conserved Domains (1) summary
      cd15382
      Location:21 → 318
      7tmA_AKHR; adipokinetic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. NM_001262792.4 → NP_001249721.1  G-protein coupled receptors family 1 profile domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001249721.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H1ZUW9
      Conserved Domains (1) summary
      cd15382
      Location:21 → 318
      7tmA_AKHR; adipokinetic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
    Nucleotide Protein
    Heading Accession and Version

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