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    acs-20 Long-chain-fatty-acid--CoA ligase [ Caenorhabditis elegans ]

    Gene ID: 178190, updated on 9-Dec-2024

    Summary

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    Official Symbol
    acs-20
    Official Full Name
    Long-chain-fatty-acid--CoA ligase
    Primary source
    WormBase:WBGene00009218
    Locus tag
    CELE_F28D1.9
    See related
    AllianceGenome:WB:WBGene00009218
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable long-chain fatty acid transmembrane transporter activity and long-chain fatty acid-CoA ligase activity. Predicted to be involved in long-chain fatty acid import into cell and long-chain fatty acid metabolic process. Located in intracellular membrane-bounded organelle. Is expressed in several structures, including enteric muscle; hypodermis; intestine; pharynx; and vulval muscle. Orthologous to human SLC27A1 (solute carrier family 27 member 1) and SLC27A4 (solute carrier family 27 member 4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See acs-20 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    10
    Sequence:
    Chromosome: IV; NC_003282.8 (12392121..12398706, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Small ribosomal subunit protein uS12 Neighboring gene putative dolichol-phosphate mannosyltransferase subunit 3 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Two very long chain fatty acid acyl-CoA synthetase genes, acs-20 and acs-22, have roles in the cuticle surface barrier in Caenorhabditis elegans. Kage-Nakadai E, et al. PLoS One, 2010 Jan 25. PMID 20111596, Free PMC Article
    2. ACS-20/FATP4 mediates the anti-ageing effect of dietary restriction in C. elegans. Wang Z, et al. Nat Commun, 2023 Nov 24. PMID 38001113, Free PMC Article
    3. Iron Overload Coordinately Promotes Ferritin Expression and Fat Accumulation in Caenorhabditis elegans. Wang H, et al. Genetics, 2016 May. PMID 27017620, Free PMC Article
    4. A lipid transfer protein ensures nematode cuticular impermeability. Njume FN, et al. iScience, 2022 Nov 18. PMID 36339267, Free PMC Article
    5. Multi-omics analysis identifies essential regulators of mitochondrial stress response in two wild-type C. elegans strains. Gao AW, et al. iScience, 2022 Feb 18. PMID 35118355, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables long-chain fatty acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables long-chain fatty acid-CoA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in long-chain fatty acid import into cell IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in long-chain fatty acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Long-chain-fatty-acid--CoA ligase
    NP_502367.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      12392121..12398706 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_069966.10 → NP_502367.3  Long-chain-fatty-acid--CoA ligase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_502367.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q19878
      Conserved Domains (2) summary
      cd05939
      Location:134 → 650
      hsFATP4_like; Fatty acid transport proteins (FATP), including FATP4 and FATP1, and similar proteins
      PRK08279
      Location:119 → 684
      PRK08279; long-chain-acyl-CoA synthetase; Validated
    Nucleotide Protein
    Heading Accession and Version

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