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    prx-6 AAA+ ATPase domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 266912, updated on 9-Dec-2024

    Summary

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    Official Symbol
    prx-6
    Official Full Name
    AAA+ ATPase domain-containing protein
    Primary source
    WormBase:WBGene00004195
    Locus tag
    CELE_F39G3.7
    See related
    AllianceGenome:WB:WBGene00004195
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ATP hydrolysis activity. Involved in nematode larval development. Predicted to be located in cytoplasm and membrane. Predicted to be active in cytosol and peroxisomal membrane. Is expressed in hypodermis and intestine. Human ortholog(s) of this gene implicated in Heimler syndrome 2; Peroxisome biogenesis disorder 4B; and peroxisome biogenesis disorder 4A. Orthologous to human PEX6 (peroxisomal biogenesis factor 6). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See prx-6 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    7
    Sequence:
    Chromosome: V; NC_003283.11 (4715388..4720093, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene Acyltransferase Neighboring gene Cytochrome b561 domain-containing protein Neighboring gene Cytochrome b561 domain-containing protein Neighboring gene TGF-beta family profile domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Peroxisome protein transportation affects metabolism of branched-chain fatty acids that critically impact growth and development of C. elegans. Wang R, et al. PLoS One, 2013. PMID 24086720, Free PMC Article
    2. Modeling human peroxisome biogenesis disorders in the nematode Caenorhabditis elegans. Thieringer H, et al. J Cell Sci, 2003 May 1. PMID 12665560
    3. Spatiotemporal contact between peroxisomes and lipid droplets regulates fasting-induced lipolysis via PEX5. Kong J, et al. Nat Commun, 2020 Jan 29. PMID 31996685, Free PMC Article
    4. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in nematode larval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein import into peroxisome matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein unfolding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in peroxisomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    AAA+ ATPase domain-containing protein
    NP_504268.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      4715388..4720093 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_071867.6 → NP_504268.1  AAA+ ATPase domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_504268.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EFR8
      Conserved Domains (1) summary
      TIGR01243
      Location:261 → 714
      CDC48; AAA family ATPase, CDC48 subfamily
    Nucleotide Protein
    Heading Accession and Version

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