dhrs-4 Dehydrogenase/reductase SDR family member 4 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: dhrs-4
Official Full Name: Dehydrogenase/reductase SDR family member 4
Primary source: WormBase:WBGene00010063
Locus tag: CELE_F54F3.4
See related: AllianceGenome:WB:WBGene00010063
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables carbonyl reductase (NADPH) activity. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See dhrs-4 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 4

Sequence:: Chromosome: V; NC_003283.11 (12922608..12924156)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

this study describes the crystal structure of the full- length recombinant C. elegans DHRS4 that was pro- duced in E. coli .
Title: Crystal structure and catalytic characterization of the dehydrogenase/reductase SDR family member 4 (DHRS4) from Caenorhabditis elegans.
This locus represents the C. elegans DHRS4 gene, which is the ortholog of the human DHRS4 gene.
Title: Molecular and functional evolution of human DHRS2 and DHRS4 duplicated genes.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F54F3.4 (e-PCR)
- UniSTS:311792

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables carbonyl reductase (NADPH) activity	IBA Inferred from Biological aspect of Ancestor more info
enables carbonyl reductase (NADPH) activity	IDA Inferred from Direct Assay more info	PubMed
enables carbonyl reductase (NADPH) activity	IEA Inferred from Electronic Annotation more info
enables catalytic activity	IDA Inferred from Direct Assay more info	PubMed
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Dehydrogenase/reductase SDR family member 4

NP_506230.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

12922608..12924156

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_073829.6 → NP_506230.1 Dehydrogenase/reductase SDR family member 4 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_506230.1

Status: REVIEWED

UniProtKB/Swiss-Prot

G5EGA6

Conserved Domains (1) summary

cl21454
Location:9 → 260

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins