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    dpf-6 Dipeptidyl peptidase family member 6 [ Caenorhabditis elegans ]

    Gene ID: 176132, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dpf-6
    Official Full Name
    Dipeptidyl peptidase family member 6
    Primary source
    WormBase:WBGene00001059
    Locus tag
    CELE_F44B9.1
    See related
    AllianceGenome:WB:WBGene00001059
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in plasma membrane. Is expressed in intestine and pharynx. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See dpf-6 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    8
    Sequence:
    Chromosome: III; NC_003281.10 (8038241..8041329)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Phospholipase A2 Neighboring gene Uncharacterized protein Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Roles of the HIF-1 hypoxia-inducible factor during hypoxia response in Caenorhabditis elegans. Shen C, et al. J Biol Chem, 2005 May 27. PMID 15781453
    2. Transcriptomics of ivermectin response in Caenorhabditis elegans: Integrating abamectin quantitative trait loci and comparison to the Ivermectin-exposed DA1316 strain. Dube F, et al. PLoS One, 2023. PMID 37141255, Free PMC Article
    3. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables aminopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Dipeptidyl peptidase family member 6
    NP_001370390.1
    • Confirmed by transcript evidence
    NP_741240.1
    • Confirmed by transcript evidence
    NP_741242.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      8038241..8041329
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_171203.7 → NP_741240.1  Dipeptidyl peptidase family member 6 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741240.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34422, Q8MQ47, Q8MQ48, Q8MQ49
      Conserved Domains (2) summary
      COG1506
      Location:15 → 661
      DAP2; Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism]
      pfam00326
      Location:445 → 662
      Peptidase_S9; Prolyl oligopeptidase family

    2. NM_001382930.2 → NP_001370390.1  Dipeptidyl peptidase family member 6 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      COG1506
      Location:15 → 556
      DAP2; Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism]

    3. NM_171205.6 → NP_741242.1  Dipeptidyl peptidase family member 6 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741242.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34422
      Conserved Domains (2) summary
      COG0657
      Location:127 → 408
      Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
      pfam00326
      Location:216 → 433
      Peptidase_S9; Prolyl oligopeptidase family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P34422.2

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