klp-6 Kinesin-like protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: klp-6
Official Full Name: Kinesin-like protein
Primary source: WormBase:WBGene00002218
Locus tag: CELE_R144.1
See related: AllianceGenome:WB:WBGene00002218
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable ATP hydrolysis activity; microtubule binding activity; and microtubule motor activity. Predicted to be involved in vesicle transport along microtubule. Located in several cellular components, including dendrite; neuronal cell body; and non-motile cilium. Is expressed in head; nervous system; tail; and in male. Used to study autosomal dominant polycystic kidney disease. Orthologous to human KIF28P (kinesin family member 28, pseudogene). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See klp-6 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 13

Sequence:: Chromosome: III; NC_003281.10 (5030929..5036583)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Comparative analysis of two Caenorhabditis elegans kinesins KLP-6 and UNC-104 reveals a common and distinct activation mechanism in kinesin-3.
Title: Comparative analysis of two Caenorhabditis elegans kinesins KLP-6 and UNC-104 reveals a common and distinct activation mechanism in kinesin-3.
This study demonstrates that the cell-specific kinesin-3 KLP-6 acts as a modulator of both intraflagellar transport dynamics and length in the cephalic male cilia of Caenorhabditis elegans.
Title: Kinesin-3 KLP-6 regulates intraflagellar transport in male-specific cilia of Caenorhabditis elegans.
KLP-6 kinesin is required for male mating behaviors and polycystin localization in sensory neuron cilia.
Title: The KLP-6 kinesin is required for male mating behaviors and polycystin localization in Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

R144.1 (e-PCR)
- UniSTS:306349

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables cytoskeletal motor activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IEA Inferred from Electronic Annotation more info
enables microtubule motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule motor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in microtubule-based movement	IEA Inferred from Electronic Annotation more info
involved_in vesicle transport along microtubule	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
part_of kinesin complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in mitochondrial membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in non-motile cilium	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Kinesin-like protein

NP_498069.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

5030929..5036583

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_065668.6 → NP_498069.1 Kinesin-like protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_498069.1

Status: REVIEWED

UniProtKB/TrEMBL

G5EFQ4

Conserved Domains (5) summary

smart00129
Location:6 → 365

KISc; Kinesin motor, catalytic domain. ATPase

cd00060
Location:449 → 549

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd01365
Location:5 → 365

KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins

pfam02050
Location:365 → 448

FliJ; Flagellar FliJ protein

pfam12423
Location:659 → 699

KIF1B; Kinesin protein 1B