nac-2 Sodium-dependent high-affinity dicarboxylate transporter 2 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: nac-2
Official Full Name: Sodium-dependent high-affinity dicarboxylate transporter 2
Primary source: WormBase:WBGene00003518
Locus tag: CELE_R107.1
See related: AllianceGenome:WB:WBGene00003518
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables citrate transmembrane transporter activity and succinate transmembrane transporter activity. Involved in several processes, including carboxylic acid transport; determination of adult lifespan; and regulation of growth. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in intestine; rect_D; rect_VL; and rect_VR. Orthologous to human SLC13A2 (solute carrier family 13 member 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See nac-2 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 13

Sequence:: Chromosome: III; NC_003281.10 (9038779..9043300, complement)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Knockdown of Indy/CeNAC2 increased life span by 22+/-3 % compared to controls, together with a decrease in whole body fat content by ~50%. Indy/CeNAC2 reduction also increased the activation of the intracellular energy sensor AMPK/aak2.
Title: Knockdown of Indy/CeNac2 extends Caenorhabditis elegans life span by inducing AMPK/aak-2.
ceNAC-2 mediates the Na+-coupled electrogenic transport of various intermediates of the citric acid cycle. Its loss leads to a significant increase in life span, but also causes a significant decrease in body size and fat content.
Title: Relevance of NAC-2, an Na+-coupled citrate transporter, to life span, body size and fat content in Caenorhabditis elegans.

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General gene information

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Markers

R107.1 (e-PCR)
- UniSTS:311611

R107.2 (e-PCR)
- UniSTS:314820

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables citrate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables citrate transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables succinate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables succinate transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables symporter activity	IEA Inferred from Electronic Annotation more info
enables transmembrane transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in citrate transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in citrate transport	IDA Inferred from Direct Assay more info	PubMed
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sodium ion transport	IEA Inferred from Electronic Annotation more info
involved_in succinate transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in succinate transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in succinate transport	IDA Inferred from Direct Assay more info	PubMed
involved_in transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Sodium-dependent high-affinity dicarboxylate transporter 2

NP_001254976.1

Confirmed by transcript evidence

NP_001254977.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

9038779..9043300 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001268047.2 → NP_001254976.1 Sodium-dependent high-affinity dicarboxylate transporter 2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001254976.1

Status: REVIEWED

UniProtKB/TrEMBL

H9G2P8

Conserved Domains (2) summary

COG0471
Location:43 → 564

CitT; Di- and tricarboxylate transporter [Carbohydrate transport and metabolism]

cl21473
Location:72 → 552

ArsB_NhaD_permease; Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices ...
NM_001268048.2 → NP_001254977.1 Sodium-dependent high-affinity dicarboxylate transporter 2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001254977.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P32739, Q86MC8

Conserved Domains (2) summary

COG0471
Location:9 → 530

CitT; Di- and tricarboxylate transporter [Carbohydrate transport and metabolism]

cl21473
Location:38 → 518

ArsB_NhaD_permease; Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices ...