sti-1 Stress-induced-phosphoprotein 1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: sti-1
Official Full Name: Stress-induced-phosphoprotein 1
Primary source: WormBase:WBGene00019983
Locus tag: CELE_R09E12.3
See related: AllianceGenome:WB:WBGene00019983
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables ATPase inhibitor activity; Hsp70 protein binding activity; and Hsp90 protein binding activity. Involved in determination of adult lifespan and response to heat. Located in cytoplasm. Is expressed in several structures, including gonad; male-specific anatomical entity; nervous system; pharynx; and vulva. Orthologous to human STIP1 (stress induced phosphoprotein 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See sti-1 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 4

Sequence:: Chromosome: V; NC_003283.11 (773518..774775)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CeSTI-1 is a cochaperone protein that may maintain homeostatic functions during episodes of stress and can regulate longevity in nematodes.
Title: C. elegans STI-1, the homolog of Sti1/Hop, is involved in aging and stress response.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

R09E12.4 (e-PCR)
- UniSTS:316967

R09E12.3 (e-PCR)
- UniSTS:312123

STS5-109 (e-PCR)
- UniSTS:242268

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATPase inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables Hsp70 protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables Hsp90 protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in reproductive process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to heat	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Stress-induced-phosphoprotein 1

NP_001367444.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

773518..774775

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001380593.3 → NP_001367444.1 Stress-induced-phosphoprotein 1 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

O16259

Conserved Domains (3) summary

TIGR00990
Location:5 → 241

3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)

sd00006
Location:140 → 168

TPR; TPR repeat [structural motif]

pfam17830
Location:259 → 311

STI1; STI1 domain