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    map-2 Methionine aminopeptidase 2 [ Caenorhabditis elegans ]

    Gene ID: 178468, updated on 9-Dec-2024

    Summary

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    Official Symbol
    map-2
    Official Full Name
    Methionine aminopeptidase 2
    Primary source
    WormBase:WBGene00003130
    Locus tag
    CELE_Y116A8A.9
    See related
    AllianceGenome:WB:WBGene00003130
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables exopeptidase activity. Acts upstream of or within with a positive effect on germ cell proliferation. Predicted to be active in cytoplasm. Is expressed in intestine and rectal gland cell. Orthologous to human METAP2 (methionyl aminopeptidase 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See map-2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    7
    Sequence:
    Chromosome: IV; NC_003282.8 (16848262..16854890, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene pseudo Neighboring gene ncRNA Neighboring gene ATP-dependent RNA helicase;Helicase C-terminal domain-containing protein Neighboring gene ING family member lsy-13

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The C. elegans methionine aminopeptidase 2 analog map-2 is required for germ cell proliferation. Boxem M, et al. FEBS Lett, 2004 Oct 8. PMID 15474045
    2. Mechanism and regulation of translation in C. elegans. Rhoads RE, et al. WormBook, 2006 Jan 28. PMID 18050488, Free PMC Article
    3. Distinct patterns of gene and protein expression elicited by organophosphorus pesticides in Caenorhabditis elegans. Lewis JA, et al. BMC Genomics, 2009 Apr 29. PMID 19402892, Free PMC Article
    4. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article
    5. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables aminopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aminopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables exopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables initiator methionyl aminopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloaminopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloexopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within_positive_effect germ cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Methionine aminopeptidase 2
    NP_001255906.1
    • Confirmed by transcript evidence
    NP_001255907.1
    • Confirmed by transcript evidence
    NP_001360158.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      16848262..16854890 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001268977.5 → NP_001255906.1  Methionine aminopeptidase 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255906.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U2V9
      Conserved Domains (2) summary
      cd01088
      Location:130 → 440
      MetAP2; Methionine Aminopeptidase 2. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.
      PTZ00053
      Location:70 → 444
      PTZ00053; methionine aminopeptidase 2; Provisional

    2. NM_001372970.2 → NP_001360158.1  Methionine aminopeptidase 2 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      PTZ00053
      Location:70 → 253
      PTZ00053; methionine aminopeptidase 2; Provisional

    3. NM_001268978.5 → NP_001255907.1  Methionine aminopeptidase 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255907.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      H1UBK1, H1UBK2, Q9U2V9
      Conserved Domains (1) summary
      PTZ00053
      Location:94 → 468
      PTZ00053; methionine aminopeptidase 2; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    H1UBK1.1

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