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    inx-22 Innexin [ Caenorhabditis elegans ]

    Gene ID: 171929, updated on 9-Dec-2024

    Summary

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    Official Symbol
    inx-22
    Official Full Name
    Innexin
    Primary source
    WormBase:WBGene00002144
    Locus tag
    CELE_Y47G6A.2
    See related
    AllianceGenome:WB:WBGene00002144
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable gap junction channel activity. Acts upstream of or within with a positive effect on germ cell proliferation. Acts upstream of or within with a negative effect on oocyte maturation. Located in gap junction. Is expressed in several structures, including GLR; germ cell; germ line; gonad; and somatic gonad precursor. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See inx-22 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    7
    Sequence:
    Chromosome: I; NC_003279.8 (3608518..3611829)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene RING-type domain-containing protein Neighboring gene uncharacterized protein Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene Innexin Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A Limited and Diverse Set of Suppressor Mutations Restore Function to INX-8 Mutant Hemichannels in the Caenorhabditis elegans Somatic Gonad. Starich T, et al. Biomolecules, 2020 Dec 10. PMID 33321846, Free PMC Article
    2. Two classes of gap junction channels mediate soma-germline interactions essential for germline proliferation and gametogenesis in Caenorhabditis elegans. Starich TA, et al. Genetics, 2014 Nov. PMID 25195067, Free PMC Article
    3. Somatic cAMP signaling regulates MSP-dependent oocyte growth and meiotic maturation in C. elegans. Govindan JA, et al. Development, 2009 Jul. PMID 19502483, Free PMC Article
    4. SACY-1 DEAD-Box helicase links the somatic control of oocyte meiotic maturation to the sperm-to-oocyte switch and gamete maintenance in Caenorhabditis elegans. Kim S, et al. Genetics, 2012 Nov. PMID 22887816, Free PMC Article
    5. Galphao/i and Galphas signaling function in parallel with the MSP/Eph receptor to control meiotic diapause in C. elegans. Govindan JA, et al. Curr Biol, 2006 Jul 11. PMID 16824915

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables gap junction channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables gap junction channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within_positive_effect germ cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within_negative_effect oocyte maturation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in gap junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in gap junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in gap junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Innexin
    NP_491186.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      3608518..3611829
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058785.7 → NP_491186.2  Innexin [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491186.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9N3R5
      Conserved Domains (1) summary
      pfam00876
      Location:20 → 376
      Innexin; Innexin
    Nucleotide Protein
    Heading Accession and Version

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