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    malt-1 Mucosa-associated lymphoid tissue lymphoma translocation protein 1 [ Caenorhabditis elegans ]

    Gene ID: 174135, updated on 9-Dec-2024

    Summary

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    Official Symbol
    malt-1
    Official Full Name
    Mucosa-associated lymphoid tissue lymphoma translocation protein 1
    Primary source
    WormBase:WBGene00017702
    Locus tag
    CELE_F22D3.6
    See related
    AllianceGenome:WB:WBGene00017702
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable cysteine-type endopeptidase activity. Predicted to be involved in proteolysis. Is expressed in RMG and oxygen sensory neurons. Human ortholog(s) of this gene implicated in immunodeficiency 12; lymphoma; and non-Hodgkin lymphoma. Orthologous to human MALT1 (MALT1 paracaspase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See malt-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    14
    Sequence:
    Chromosome: II; NC_003280.10 (6947855..6951300, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Folliculin;Folliculin DENN domain-containing protein;UDENN FLCN/SMCR8-type domain-containing protein Neighboring gene pseudo Neighboring gene ncRNA Neighboring gene Homeobox protein ceh-38;One cut domain family member Neighboring gene Sex-determining transformer protein 2 Neighboring gene Translation initiation factor eIF2B subunit gamma

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. MALT-1 mediates IL-17 neural signaling to regulate C. elegans behavior, immunity and longevity. Flynn SM, et al. Nat Commun, 2020 Apr 29. PMID 32350248, Free PMC Article
    2. MALT-1 shortens lifespan by inhibiting autophagy in the intestine of C. elegans. Vérièpe-Salerno J, et al. Autophagy Rep, 2023 Nov 9. PMID 38510643, Free PMC Article
    3. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MALT1 has an ancient role modulating neural circuit function downstream of IL-17 to remodel physiology and behavior.
      Title: MALT-1 mediates IL-17 neural signaling to regulate C. elegans behavior, immunity and longevity.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Mucosa-associated lymphoid tissue lymphoma translocation protein 1
    NP_495424.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      6947855..6951300 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_063023.9 → NP_495424.2  Mucosa-associated lymphoid tissue lymphoma translocation protein 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495424.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EG87
      Conserved Domains (2) summary
      pfam00656
      Location:252 → 481
      Peptidase_C14; Caspase domain
      cl11960
      Location:122 → 182
      Ig; Immunoglobulin domain
    Nucleotide Protein
    Heading Accession and Version

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