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    vps-29 Vacuolar protein sorting-associated protein 29 [ Caenorhabditis elegans ]

    Gene ID: 176424, updated on 9-Dec-2024

    Summary

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    Official Symbol
    vps-29
    Official Full Name
    Vacuolar protein sorting-associated protein 29
    Primary source
    WormBase:WBGene00014234
    Locus tag
    CELE_ZK1128.8
    See related
    AllianceGenome:WB:WBGene00014234
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in intracellular protein transport and retrograde transport, endosome to Golgi. Located in cytosol. Orthologous to human VPS29 (VPS29 retromer complex component). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See vps-29 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    4
    Sequence:
    Chromosome: III; NC_003281.10 (10111953..10113058, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene Serpentine receptor class T-55 Neighboring gene Uncharacterized protein Neighboring gene Protein arginine methyltransferase NDUFAF7 homolog, mitochondrial Neighboring gene U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Inhibition of late endosomal maturation restores Wnt secretion in Caenorhabditis elegans vps-29 retromer mutants. Lorenowicz MJ, et al. Cell Signal, 2014 Jan. PMID 24056045
    2. Some, but not all, retromer components promote morphogenesis of C. elegans sensory compartments. Oikonomou G, et al. Dev Biol, 2012 Feb 1. PMID 22138055, Free PMC Article
    3. Protein kinase CK2 is required for Wntless internalization and Wnt secretion. de Groot RE, et al. Cell Signal, 2014 Dec. PMID 25178265
    4. RNA helicase DDX3 is a regulatory subunit of casein kinase 1 in Wnt-β-catenin signaling. Cruciat CM, et al. Science, 2013 Mar 22. PMID 23413191
    5. SNX3-retromer requires an evolutionary conserved MON2:DOPEY2:ATP9A complex to mediate Wntless sorting and Wnt secretion. McGough IJ, et al. Nat Commun, 2018 Sep 13. PMID 30213940, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retrograde transport, endosome to Golgi IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of retromer complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Vacuolar protein sorting-associated protein 29
    NP_001022987.1
    • Confirmed by transcript evidence
    NP_001022988.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      10111953..10113058 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001027817.4 → NP_001022988.1  Vacuolar protein sorting-associated protein 29 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022988.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86D99
      Conserved Domains (1) summary
      cd07394
      Location:6 → 185
      MPP_Vps29; Homo sapiens Vps29 and related proteins, metallophosphatase domain

    2. NM_001027816.4 → NP_001022987.1  Vacuolar protein sorting-associated protein 29 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022987.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9XVX5
      Conserved Domains (1) summary
      cd07394
      Location:2 → 181
      MPP_Vps29; Homo sapiens Vps29 and related proteins, metallophosphatase domain
    Nucleotide Protein
    Heading Accession and Version

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