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    marc-6 RING-type E3 ubiquitin transferase [ Caenorhabditis elegans ]

    Gene ID: 172986, updated on 9-Dec-2024

    Summary

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    Official Symbol
    marc-6
    Official Full Name
    RING-type E3 ubiquitin transferase
    Primary source
    WormBase:WBGene00018847
    Locus tag
    CELE_F55A3.1
    See related
    AllianceGenome:WB:WBGene00018847
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ubiquitin-protein transferase activity. Predicted to be involved in ERAD pathway and protein polyubiquitination. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in familial adult myoclonic epilepsy 3. Orthologous to human MARCHF6 (membrane associated ring-CH-type finger 6). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See marc-6 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    8
    Sequence:
    Chromosome: I; NC_003279.8 (10799623..10806925)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene FACT complex subunit spt-16 Neighboring gene C2H2-type domain-containing protein Neighboring gene Major sperm protein Neighboring gene tRNA-Asp Neighboring gene Schlafen-like protein 3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mutations in two ERAD E3 ubiquitin ligase enzymes reduce spontaneous reversal frequency in Caenorhabditis elegans. Oswald M, et al. MicroPubl Biol, 2020 Nov 19. PMID 33274327, Free PMC Article
    2. ER E3 ubiquitin ligase HRD-1 and its specific partner chaperone BiP play important roles in ERAD and developmental growth in Caenorhabditis elegans. Sasagawa Y, et al. Genes Cells, 2007 Sep. PMID 17825049
    3. BK channel density is regulated by endoplasmic reticulum associated degradation and influenced by the SKN-1A/NRF1 transcription factor. Cheung TP, et al. PLoS Genet, 2020 Jun. PMID 32502151, Free PMC Article
    4. ER proteostasis regulators cell-non-autonomously control sleep. Kawano T, et al. Cell Rep, 2023 Mar 28. PMID 36924492
    5. Ubiquitin-mediated pathways in C. elegans. Kipreos ET. WormBook, 2005 Dec 1. PMID 18050424, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ubiquitin-protein transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in multicellular organism growth IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein polyubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    RING-type E3 ubiquitin transferase
    NP_492823.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      10799623..10806925
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_060422.7 → NP_492823.2  RING-type E3 ubiquitin transferase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492823.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      G4S684, Q400N4
      Conserved Domains (2) summary
      COG5183
      Location:47 → 1016
      SSM4; E3 ubiquitin-protein ligase DOA10 [Posttranslational modification, protein turnover, chaperones]
      cd16702
      Location:52 → 98
      RING_CH-C4HC3_MARCH6; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING-CH6 (MARCH6)
    Nucleotide Protein
    Heading Accession and Version

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