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    atm-1 Serine/threonine-protein kinase ATM [ Caenorhabditis elegans ]

    Gene ID: 3565793, updated on 9-Dec-2024

    Summary

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    Official Symbol
    atm-1
    Official Full Name
    Serine/threonine-protein kinase ATM
    Primary source
    WormBase:WBGene00000227
    Locus tag
    CELE_Y48G1BL.2
    See related
    AllianceGenome:WB:WBGene00000227
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ATP binding activity; protein serine kinase activity; and protein serine/threonine kinase activity. Involved in response to ionizing radiation. Located in chromatin. Used to study ataxia telangiectasia. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); endocrine gland cancer (multiple); lung carcinoma (multiple); neurodegenerative disease (multiple); and senile cataract. Orthologous to human ATM (ATM serine/threonine kinase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See atm-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    28
    Sequence:
    Chromosome: I; NC_003279.8 (183364..208384)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene MARVEL domain-containing protein Neighboring gene Sulfhydryl oxidase Neighboring gene tRNA Neighboring gene Carbohydrate sulfotransferase Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The atm-1 gene is required for genome stability in Caenorhabditis elegans. Jones MR, et al. Mol Genet Genomics, 2012 Apr. PMID 22350747, Free PMC Article
    2. Efficient collection of a large number of mutations by mutagenesis of DNA damage response defective animals. Suehiro Y, et al. Sci Rep, 2021 Apr 7. PMID 33828169, Free PMC Article
    3. NAD(+) Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair. Fang EF, et al. Cell Metab, 2016 Oct 11. PMID 27732836, Free PMC Article
    4. Interaction between Radioadaptive Response and Radiation-Induced Bystander Effect in Caenorhabditis elegans : A Unique Role of the DNA Damage Checkpoint. Tang H, et al. Radiat Res, 2016 Dec. PMID 27874324
    5. ATM Induces Cell Death with Autophagy in Response to H(2)O(2) Specifically in Caenorhabditis elegans Nondividing Cells. Moriwaki T, et al. Oxid Med Cell Longev, 2018. PMID 30057676, Free PMC Article

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The data suggest a model in which ATM-1 and ATL-1 have antagonistic roles in very early repair processing, but are redundantly required for accumulation of the RAD-51 recombinase at double-strand breaks sites.
      Title: ATM and ATR Influence Meiotic Crossover Formation Through Antagonistic and Overlapping Functions in Caenorhabditis elegans.
    2. Study finds that the ATM-1transcript is in fact a product of three gene predictions, Y48G1BL.2 (atm-1), K10E9.1, and F56C11.4 that together make up the complete coding region of ATM-1.
      Title: The atm-1 gene is required for genome stability in Caenorhabditis elegans.
    3. WRN-1 functions together with RPA-1 upstream of ATM and ATR to trigger cell cycle arrest in response to double-strand DNA breaks.
      Title: The Caenorhabditis elegans Werner syndrome protein functions upstream of ATR and ATM in response to DNA replication inhibition and double-strand DNA breaks.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to ionizing radiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Serine/threonine-protein kinase ATM
    NP_001293214.1
    • Confirmed by transcript evidence
    NP_001293215.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      183364..208384
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001306285.3 → NP_001293214.1  Serine/threonine-protein kinase ATM [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293214.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9N3Q4, V6CJ63, V6CKB4
      Conserved Domains (2) summary
      cd05171
      Location:2041 → 2313
      PIKKc_ATM; Catalytic domain of Ataxia Telangiectasia Mutated
      pfam02260
      Location:2353 → 2378
      FATC; FATC domain

    2. NM_001306286.3 → NP_001293215.1  Serine/threonine-protein kinase ATM [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293215.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9N3Q4
      Conserved Domains (2) summary
      cd05171
      Location:1364 → 1636
      PIKKc_ATM; Catalytic domain of Ataxia Telangiectasia Mutated
      pfam02260
      Location:1676 → 1701
      FATC; FATC domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9N3Q4.3

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