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    elo-9 Elongation of very long chain fatty acids protein [ Caenorhabditis elegans ]

    Gene ID: 190207, updated on 9-Dec-2024

    Summary

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    Official Symbol
    elo-9
    Official Full Name
    Elongation of very long chain fatty acids protein
    Primary source
    WormBase:WBGene00001247
    Locus tag
    CELE_Y53F4B.2
    See related
    AllianceGenome:WB:WBGene00001247
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable fatty acid elongase activity. Predicted to be involved in fatty acid biosynthetic process and sphingolipid biosynthetic process. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human ELOVL3 (ELOVL fatty acid elongase 3) and ELOVL6 (ELOVL fatty acid elongase 6). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See elo-9 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    5
    Sequence:
    Chromosome: II; NC_003280.10 (14959526..14964108, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Phosphodiesterase;putative 3',5'-cyclic phosphodiesterase pde-3 Neighboring gene ncRNA Neighboring gene Protein kinase domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Transcription factor CBF/NF-Y/archaeal histone domain-containing protein Neighboring gene 26S rRNA (cytosine-C(5))-methyltransferase nsun-5 Neighboring gene tRNA N(3)-methylcytidine methyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Eicosapentaenoic acid influences the pathogenesis of Candida albicans in Caenorhabditis elegans via inhibition of hyphal formation and stimulation of the host immune response. Mokoena NZ, et al. Med Microbiol Immunol, 2023 Oct. PMID 37672050, Free PMC Article
    2. Fatty acid desaturation and the regulation of adiposity in Caenorhabditis elegans. Brock TJ, et al. Genetics, 2007 Jun. PMID 17435249, Free PMC Article
    3. Meta-Analysis of Caenorhabditis elegans Transcriptomics Implicates Hedgehog-Like Signaling in Host-Microbe Interactions. Zárate-Potes A, et al. Front Microbiol, 2022. PMID 35620104, Free PMC Article
    4. Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. Zhang Y, et al. BMC Genomics, 2013 Mar 12. PMID 23496871, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables fatty acid elongase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fatty acid elongase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fatty acid elongation, monounsaturated fatty acid IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid elongation, polyunsaturated fatty acid IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid elongation, saturated fatty acid IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sphingolipid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in very long-chain fatty acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Elongation of very long chain fatty acids protein
    NP_497086.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      14959526..14964108 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_064685.3 → NP_497086.1  Elongation of very long chain fatty acids protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_497086.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9NAC6
      Conserved Domains (1) summary
      pfam01151
      Location:44 → 274
      ELO; GNS1/SUR4 family
    Nucleotide Protein
    Heading Accession and Version

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