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    snt-6 C2 domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 182427, updated on 9-Dec-2024

    Summary

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    Official Symbol
    snt-6
    Official Full Name
    C2 domain-containing protein
    Primary source
    WormBase:WBGene00004926
    Locus tag
    CELE_C08G5.4
    See related
    AllianceGenome:WB:WBGene00004926
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable SNARE binding activity; calcium ion sensor activity; and calcium-dependent phospholipid binding activity. Predicted to be involved in calcium-dependent activation of synaptic vesicle fusion; regulation of calcium ion-dependent exocytosis; and vesicle fusion. Predicted to be located in membrane. Predicted to be active in several cellular components, including axon; exocytic vesicle; and synapse. Orthologous to human SYT7 (synaptotagmin 7). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See snt-6 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    8
    Sequence:
    Chromosome: II; NC_003280.10 (745418..750212, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene F-box C protein Neighboring gene pseudo Neighboring gene ncRNA Neighboring gene EGF-like domain-containing protein;GED domain-containing protein Neighboring gene 7TM_GPCR_Srx domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    2. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    3. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables SNARE binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion sensor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium-dependent phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcium-dependent activation of synaptic vesicle fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of calcium ion-dependent exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in exocytic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    C2 domain-containing protein
    NP_001254022.1
    • Confirmed by transcript evidence
    NP_001254023.1
    • Confirmed by transcript evidence
    NP_001305208.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      745418..750212 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001267094.2 → NP_001254023.1  C2 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254023.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9TZL3
      Conserved Domains (2) summary
      cd00276
      Location:126 → 261
      C2B_Synaptotagmin; C2 domain second repeat present in Synaptotagmin
      cl14603
      Location:67 → 117
      C2; C2 domain

    2. NM_001267093.2 → NP_001254022.1  C2 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254022.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G4RXP2
      Conserved Domains (2) summary
      cd00276
      Location:234 → 369
      C2B_Synaptotagmin; C2 domain second repeat present in Synaptotagmin
      cl14603
      Location:101 → 225
      C2; C2 domain

    3. NM_001318279.3 → NP_001305208.1  C2 domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0S4XQZ9
      Conserved Domains (2) summary
      cd00276
      Location:58 → 193
      C2B_Synaptotagmin; C2 domain second repeat present in Synaptotagmin
      cl14603
      Location:1 → 49
      C2; C2 domain
    Nucleotide Protein
    Heading Accession and Version

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