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    mff-1 Mitochondrial fission factor [ Caenorhabditis elegans ]

    Gene ID: 181430, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mff-1
    Official Full Name
    Mitochondrial fission factor
    Primary source
    WormBase:WBGene00008691
    Locus tag
    CELE_F11C1.2
    See related
    AllianceGenome:WB:WBGene00008691
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in mitochondrial fission; positive regulation of mitochondrial fission; and positive regulation of protein targeting to membrane. Predicted to be located in mitochondrial outer membrane and peroxisome. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See mff-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    5
    Sequence:
    Chromosome: X; NC_003284.9 (12985790..12987219, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene 1-phosphatidylinositol-3-phosphate 5-kinase Neighboring gene Photosystem reaction center subunit H Neighboring gene Lipid droplet-associated hydrolase Neighboring gene Uncharacterized protein Neighboring gene SCAVenger receptor (CD36 family) related Neighboring gene CHCH domain-containing protein Neighboring gene Mitochondrial fission factor Neighboring gene ATPase dynein-related AAA domain-containing protein;VWFA domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural recognition of the mRNA 3' UTR by PUF-8 restricts the lifespan of C. elegans. Xu Z, et al. Nucleic Acids Res, 2021 Sep 27. PMID 34478557, Free PMC Article
    2. Mutations in Fis1 disrupt orderly disposal of defective mitochondria. Shen Q, et al. Mol Biol Cell, 2014 Jan. PMID 24196833, Free PMC Article
    3. Alcohol induces mitochondrial fragmentation and stress responses to maintain normal muscle function in Caenorhabditis elegans. Oh KH, et al. FASEB J, 2020 Jun. PMID 32294300, Free PMC Article
    4. Disruption of mitochondrial dynamics increases stress resistance through activation of multiple stress response pathways. Machiela E, et al. FASEB J, 2020 Jun. PMID 32385951, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in mitochondrial fission IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of mitochondrial fission IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of protein targeting to membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in peroxisome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Mitochondrial fission factor
    NP_510158.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      12985790..12987219 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_077757.6 → NP_510158.2  Mitochondrial fission factor [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_510158.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q19343
    Nucleotide Protein
    Heading Accession and Version

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