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    che-13 Intraflagellar transport protein che-13 [ Caenorhabditis elegans ]

    Gene ID: 186607, updated on 9-Dec-2024

    Summary

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    Official Symbol
    che-13
    Official Full Name
    Intraflagellar transport protein che-13
    Primary source
    WormBase:WBGene00000492
    Locus tag
    CELE_F59C6.7
    See related
    AllianceGenome:WB:WBGene00000492
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in chemosensory behavior; cilium organization; and protein localization. Located in axoneme; ciliary basal body; and ciliary transition zone. Part of intraciliary transport particle B. Is expressed in neurons. Used to study ciliopathy. Human ortholog(s) of this gene implicated in orofaciodigital syndrome XVIII. Orthologous to human IFT57 (intraflagellar transport 57). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See che-13 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    10
    Sequence:
    Chromosome: I; NC_003279.8 (10506998..10515586, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Mothers against decapentaplegic homolog Neighboring gene ncRNA Neighboring gene Glycosyltransferase family 92 protein F59C6.8 Neighboring gene Neuropeptide-Like Protein Neighboring gene FMRF-Like Peptide Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A role of ADF chemosensory neurones in dauer formation behaviour in C. elegans. Shakir MA, et al. Neuroreport, 1993 Sep 3. PMID 8219008
    2. Worms with a single functional sensory cilium generate proper neuron-specific behavioral output. Senti G, et al. Genetics, 2009 Oct. PMID 19652182, Free PMC Article
    3. Identification of CHE-13, a novel intraflagellar transport protein required for cilia formation. Haycraft CJ, et al. Exp Cell Res, 2003 Apr 1. PMID 12651157
    4. XBX-1 encodes a dynein light intermediate chain required for retrograde intraflagellar transport and cilia assembly in Caenorhabditis elegans. Schafer JC, et al. Mol Biol Cell, 2003 May. PMID 12802075, Free PMC Article
    5. A dual mechanosensory and chemosensory neuron in Caenorhabditis elegans. Kaplan JM, et al. Proc Natl Acad Sci U S A, 1993 Mar 15. PMID 8460126, Free PMC Article

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in chemosensory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cilium assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in intraciliary anterograde transport IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in intraciliary retrograde transport IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in intraciliary transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in non-motile cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in non-motile cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in axoneme IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in ciliary basal body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in ciliary basal body ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in ciliary transition zone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cilium IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of intraciliary transport particle B IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of intraciliary transport particle B IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in microtubule organizing center IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Intraflagellar transport protein che-13
    NP_001251397.1
    • Confirmed by transcript evidence
    NP_001251398.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      10506998..10515586 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001264468.3 → NP_001251397.1  Intraflagellar transport protein che-13 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001251397.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      E9P884, Q93833
      Conserved Domains (1) summary
      pfam10498
      Location:37 → 393
      IFT57; Intra-flagellar transport protein 57

    2. NM_001264469.3 → NP_001251398.1  Intraflagellar transport protein che-13 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001251398.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q93833
      Conserved Domains (1) summary
      pfam10498
      Location:33 → 306
      IFT57; Intra-flagellar transport protein 57
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q93833.2

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