vps-50 Vps54_N domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: vps-50
Official Full Name: Vps54_N domain-containing protein
Primary source: WormBase:WBGene00008078
Locus tag: CELE_C44B9.1
See related: AllianceGenome:WB:WBGene00008078
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable SNARE binding activity. Involved in positive regulation of dense core granule transport and positive regulation of locomotion involved in locomotory behavior. Predicted to be located in cytosol. Predicted to be part of EARP complex. Is expressed in nervous system. Orthologous to human VPS50 (VPS50 subunit of EARP/GARPII complex). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See vps-50 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 7

Sequence:: Chromosome: III; NC_003281.10 (10869193..10874813)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

An evolutionarily conserved C. elegans protein, VPS-50, that is required for animals to assume the well-fed behavioral state. Both VPS-50 and its murine homolog mVPS50 are expressed in neurons, are associated with synaptic and dense-core vesicles, and control vesicle acidification and hence synaptic function, likely through regulation of the assembly of the V-ATPase complex.
Title: The Conserved VPS-50 Protein Functions in Dense-Core Vesicle Maturation and Acidification and Controls Animal Behavior.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C44B9.1 (e-PCR)
- UniSTS:307334

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables SNARE binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in endocytic recycling	IBA Inferred from Biological aspect of Ancestor more info
involved_in endocytic recycling	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of dense core granule transport	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of dense core granule transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of locomotion involved in locomotory behavior	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of locomotion involved in locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in retrograde transport, endosome to Golgi	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of EARP complex	IBA Inferred from Biological aspect of Ancestor more info
part_of EARP complex	IEA Inferred from Electronic Annotation more info
part_of EARP complex	TAS Traceable Author Statement more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Vps54_N domain-containing protein

NP_499394.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

10869193..10874813

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_066993.3 → NP_499394.2 Vps54_N domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_499394.2

Status: REVIEWED

UniProtKB/TrEMBL

Q18602

Conserved Domains (2) summary

pfam10474
Location:703 → 953

DUF2451; Protein of unknown function C-terminus (DUF2451)

pfam10475
Location:76 → 363

DUF2450; Protein of unknown function N-terminal domain (DUF2450)