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    nhr-114 Nuclear hormone receptor 114 [ Caenorhabditis elegans ]

    Gene ID: 178821, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nhr-114
    Official Full Name
    Nuclear hormone receptor 114
    Primary source
    WormBase:WBGene00003704
    Locus tag
    CELE_Y45G5AM.1
    See related
    AllianceGenome:WB:WBGene00003704
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and nuclear receptor activity. Involved in regulation of gene expression. Acts upstream of with a positive effect on S-adenosylmethionine cycle. Located in nucleus. Is expressed in germ line; hypodermis; and intestine. Human ortholog(s) of this gene implicated in cerebral infarction; cerebrovascular disease; myocardial infarction; and obesity. Orthologous to human NR1H3 (nuclear receptor subfamily 1 group H member 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See nhr-114 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    7
    Sequence:
    Chromosome: V; NC_003283.11 (4187202..4190008)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Cilia- and flagella-associated protein 157 Neighboring gene Rad21/Rec8-like protein C-terminal eukaryotic domain-containing protein Neighboring gene Protein pid-5 Neighboring gene Aftiphilin clathrin-binding box domain-containing protein;Clathrin_bdg domain-containing protein;Transcription factor Neighboring gene Dolichyl-phosphate beta-glucosyltransferase;dolichyl-phosphate beta-glucosyltransferase Neighboring gene DNA-directed RNA polymerase RpoA/D/Rpb3-type domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The antidiabetic drug metformin aids bacteria in hijacking vitamin B12 from the environment through RcdA. Yao L, et al. Commun Biol, 2023 Jan 24. PMID 36693976, Free PMC Article
    2. Diet and genetics: Trp-ing over food sensitivity. Hubbard EJ. Curr Biol, 2013 Apr 22. PMID 23618671
    3. Fertility and germline stem cell maintenance under different diets requires nhr-114/HNF4 in C. elegans. Gracida X, et al. Curr Biol, 2013 Apr 8. PMID 23499532
    4. Transcription Factor Activity Mapping of a Tissue-Specific in vivo Gene Regulatory Network. MacNeil LT, et al. Cell Syst, 2015 Aug 26. PMID 26430702, Free PMC Article
    5. Caenorhabditis elegans methionine/S-adenosylmethionine cycle activity is sensed and adjusted by a nuclear hormone receptor. Giese GE, et al. Elife, 2020 Oct 5. PMID 33016879, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Fertility and germline stem cell maintenance under different diets requires nhr-114/HNF4 in C. elegans.
      Title: Fertility and germline stem cell maintenance under different diets requires nhr-114/HNF4 in C. elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclear receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_positive_effect S-adenosylmethionine cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Nuclear hormone receptor 114
    NP_001024242.1
    • Confirmed by transcript evidence
    NP_001317845.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      4187202..4190008
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001029071.5 → NP_001024242.1  Nuclear hormone receptor 114 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024242.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A168HAV7, G5EEM0, Q86PI7
      Conserved Domains (2) summary
      cd06960
      Location:15 → 90
      NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers
      smart00430
      Location:218 → 379
      HOLI; Ligand binding domain of hormone receptors

    2. NM_001330839.3 → NP_001317845.1  Nuclear hormone receptor 114 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A168HAV7
      Conserved Domains (1) summary
      smart00430
      Location:20 → 104
      HOLI; Ligand binding domain of hormone receptors

    RNA

    1. NR_138521.1 RNA Sequence

      Status: REVIEWED

    2. NR_138520.1 RNA Sequence

      Status: REVIEWED

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G5EEM0.1

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