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    tln-1 FERM domain-containing protein;I/LWEQ domain-containing protein;Talin central domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 171736, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tln-1
    Official Full Name
    FERM domain-containing protein;I/LWEQ domain-containing protein;Talin central domain-containing protein
    Primary source
    WormBase:WBGene00006771
    Locus tag
    CELE_Y71G12B.11
    See related
    AllianceGenome:WB:WBGene00006771
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable integrin binding activity. Involved in negative regulation of epidermal growth factor receptor signaling pathway; regulation of vulval development; and vulval cell fate specification. Located in basement membrane; contractile muscle fiber; and lateral plasma membrane. Is expressed in several structures, including Psub3; Psub4; Z2; Z3; and distal tip cell. Orthologous to several human genes including TLN2 (talin 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See tln-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    12
    Sequence:
    Chromosome: I; NC_003279.8 (1721590..1740692)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene RING-type domain-containing protein Neighboring gene Autophagy-related protein 5 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Mitochondrial-processing peptidase subunit alpha Neighboring gene hydroxymethylglutaryl-CoA lyase Neighboring gene ML domain-containing protein;RING-type domain-containing protein;Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An integrin binding motif in TLN-1/talin plays a minor role in motility and ovulation. Sadeghian F, et al. MicroPubl Biol, 2023. PMID 36685729, Free PMC Article
    2. Talin requires beta-integrin, but not vinculin, for its assembly into focal adhesion-like structures in the nematode Caenorhabditis elegans. Moulder GL, et al. Mol Biol Cell, 1996 Aug. PMID 8856663, Free PMC Article
    3. Meiotic pairing behavior of two free duplications of linkage group I in Caenorhabditis elegans. Rose AM, et al. Mol Gen Genet, 1984. PMID 6593563
    4. Rhotekin regulates axon regeneration through the talin-Vinculin-Vinexin axis in Caenorhabditis elegans. Sakai Y, et al. PLoS Genet, 2023 Dec. PMID 38150455, Free PMC Article
    5. The RGD (Arg-Gly-Asp) is a potential cell-binding motif of UNC-52/PERLECAN. Qiu Z, et al. Biochem Biophys Res Commun, 2022 Jan 1. PMID 34844120

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The RGD (Arg-Gly-Asp) is a potential cell-binding motif of UNC-52/PERLECAN.
      Title: The RGD (Arg-Gly-Asp) is a potential cell-binding motif of UNC-52/PERLECAN.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables integrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in integrin-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of epidermal growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of vulval development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in vulval cell fate specification IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in M band IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in basement membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in focal adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in focal adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in ruffle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in striated muscle dense body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    FERM domain-containing protein;I/LWEQ domain-containing protein;Talin central domain-containing protein
    NP_001249039.1
    • Confirmed by transcript evidence
    NP_001300474.1
    • Confirmed by transcript evidence
    NP_001300476.1
    • Confirmed by transcript evidence
    NP_001359949.1
    • Confirmed by transcript evidence
    NP_001368504.1
    • Confirmed by transcript evidence
    NP_001380167.1
    • Confirmed by transcript evidence
    NP_490886.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      1721590..1740692
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001373653.2 → NP_001359949.1  FERM domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95XN3
      Conserved Domains (5) summary
      smart00295
      Location:89 → 341
      B41; Band 4.1 homologues
      cd10569
      Location:337 → 428
      FERM_C_Talin; FERM domain C-lobe/F3 of Talin
      pfam09141
      Location:525 → 683
      Talin_middle; Talin, middle domain
      pfam16511
      Location:4 → 84
      FERM_f0; N-terminal or F0 domain of Talin-head FERM
      cl19756
      Location:675 → 778
      I_LWEQ; I/LWEQ domain

    2. NM_058485.8 → NP_490886.2  FERM domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EGK1
      Conserved Domains (10) summary
      cd12150
      Location:1667 → 1839
      talin-RS; rod-segment of the talin C-terminal domain
      smart00295
      Location:89 → 341
      B41; Band 4.1 homologues
      smart00307
      Location:2357 → 2549
      ILWEQ; I/LWEQ domain
      cd10569
      Location:337 → 428
      FERM_C_Talin; FERM domain C-lobe/F3 of Talin
      pfam00373
      Location:232 → 341
      FERM_M; FERM central domain
      pfam08913
      Location:1863 → 1984
      VBS; Vinculin Binding Site
      pfam09141
      Location:525 → 683
      Talin_middle; Talin, middle domain
      pfam09379
      Location:91 → 135
      FERM_N; FERM N-terminal domain
      pfam16511
      Location:4 → 84
      FERM_f0; N-terminal or F0 domain of Talin-head FERM
      cl19756
      Location:698 → 783
      I_LWEQ; I/LWEQ domain

    3. NM_001313545.3 → NP_001300474.1  I/LWEQ domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3ATT6
      Conserved Domains (6) summary
      cd12150
      Location:1302 → 1474
      talin-RS; rod-segment of the talin C-terminal domain
      smart00307
      Location:1992 → 2184
      ILWEQ; I/LWEQ domain
      cd10569
      Location:1 → 63
      FERM_C_Talin; FERM domain C-lobe/F3 of Talin
      pfam08913
      Location:1498 → 1619
      VBS; Vinculin Binding Site
      pfam09141
      Location:160 → 318
      Talin_middle; Talin, middle domain
      cl19756
      Location:333 → 428
      I_LWEQ; I/LWEQ domain

    4. NM_001381251.1 → NP_001368504.1  Talin central domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AQU9
      Conserved Domains (3) summary
      cd10569
      Location:1 → 63
      FERM_C_Talin; FERM domain C-lobe/F3 of Talin
      pfam09141
      Location:160 → 318
      Talin_middle; Talin, middle domain
      cl19756
      Location:310 → 388
      I_LWEQ; I/LWEQ domain

    5. NM_001262110.3 → NP_001249039.1  I/LWEQ domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      G4S9F5
      Conserved Domains (4) summary
      cd12150
      Location:1004 → 1176
      talin-RS; rod-segment of the talin C-terminal domain
      smart00307
      Location:1694 → 1886
      ILWEQ; I/LWEQ domain
      TIGR02168
      Location:189 → 440
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam08913
      Location:1200 → 1321
      VBS; Vinculin Binding Site

    6. NM_001392973.1 → NP_001380167.1  I/LWEQ domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      W6SBK6
      Conserved Domains (3) summary
      cd12150
      Location:625 → 797
      talin-RS; rod-segment of the talin C-terminal domain
      smart00307
      Location:1315 → 1507
      ILWEQ; I/LWEQ domain
      pfam08913
      Location:821 → 942
      VBS; Vinculin Binding Site

    7. NM_001313547.3 → NP_001300476.1  I/LWEQ domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AUD9
      Conserved Domains (1) summary
      cl19756
      Location:5 → 54
      I_LWEQ; I/LWEQ domain
    Nucleotide Protein
    Heading Accession and Version

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