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    slc-28.2 Sodium/nucleoside cotransporter [ Caenorhabditis elegans ]

    Gene ID: 178769, updated on 9-Dec-2024

    Summary

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    Official Symbol
    slc-28.2
    Official Full Name
    Sodium/nucleoside cotransporter
    Primary source
    WormBase:WBGene00017868
    Locus tag
    CELE_F27E11.2
    See related
    AllianceGenome:WB:WBGene00017868
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable nucleoside:sodium symporter activity. Predicted to be involved in nucleoside transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to several human genes including SLC28A1 (solute carrier family 28 member 1) and SLC28A2 (solute carrier family 28 member 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See slc-28.2 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    9
    Sequence:
    Chromosome: V; NC_003283.11 (3460219..3463215)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene tRNA-Met Neighboring gene ncRNA Neighboring gene Concentrative nucleoside transporter C-terminal domain-containing protein;Sodium/nucleoside cotransporter

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A novel proton-dependent nucleoside transporter, CeCNT3, from Caenorhabditis elegans. Xiao G, et al. Mol Pharmacol, 2001 Feb. PMID 11160871
    2. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables nucleoside transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleoside:sodium symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in nucleoside transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nucleoside transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in purine nucleobase transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pyrimidine nucleobase transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pyrimidine-containing compound transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sodium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Sodium/nucleoside cotransporter
    NP_001309639.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      3460219..3463215
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001322518.4 → NP_001309639.1  Sodium/nucleoside cotransporter [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A131MBV2, Q9NDD4
      Conserved Domains (4) summary
      TIGR00804
      Location:147 → 553
      nupC; nucleoside transporter
      pfam01773
      Location:154 → 221
      Nucleos_tra2_N; Na+ dependent nucleoside transporter N-terminus
      pfam07662
      Location:341 → 553
      Nucleos_tra2_C; Na+ dependent nucleoside transporter C-terminus
      pfam07670
      Location:245 → 336
      Gate; Nucleoside recognition
    Nucleotide Protein
    Heading Accession and Version

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