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    egl-8 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase;1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8;Phosphoinositide phospholipase C [ Caenorhabditis elegans ]

    Gene ID: 178537, updated on 9-Dec-2024

    Summary

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    Official Symbol
    egl-8
    Official Full Name
    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase;1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8;Phosphoinositide phospholipase C
    Primary source
    WormBase:WBGene00001177
    Locus tag
    CELE_B0348.4
    See related
    AllianceGenome:WB:WBGene00001177
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable phosphatidylinositol phospholipase C activity. Involved in several processes, including G protein-coupled dopamine receptor signaling pathway; positive regulation of acetylcholine secretion, neurotransmission; and thermotaxis. Located in plasma membrane. Is expressed in intestine; nervous system; non-striated muscle; and vas deferens. Used to study nicotine dependence. Orthologous to human PLCB4 (phospholipase C beta 4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See egl-8 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    23
    Sequence:
    Chromosome: V; NC_003283.11 (20818..43704)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Secreted protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene LITAF domain-containing protein Neighboring gene LITAF domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evidence for a role for cyclic AMP in modulating the action of 5-HT and an excitatory neuropeptide, FLP17A, in the pharyngeal muscle of Caenorhabditis elegans. Papaioannou S, et al. Invert Neurosci, 2008 Jun. PMID 18463910
    2. Facilitation of synaptic transmission by EGL-30 Gqalpha and EGL-8 PLCbeta: DAG binding to UNC-13 is required to stimulate acetylcholine release. Lackner MR, et al. Neuron, 1999 Oct. PMID 10571228
    3. Krill oil protects dopaminergic neurons from age-related degeneration through temporal transcriptome rewiring and suppression of several hallmarks of aging. SenGupta T, et al. Aging (Albany NY), 2022 Nov 9. PMID 36367773, Free PMC Article
    4. Inositol 1,4,5-trisphosphate signalling regulates the avoidance response to nose touch in Caenorhabditis elegans. Walker DS, et al. PLoS Genet, 2009 Sep. PMID 19730689, Free PMC Article
    5. Neuronal and intestinal protein kinase d isoforms mediate Na+ (salt taste)-induced learning. Fu Y, et al. Sci Signal, 2009 Aug 11. PMID 19671928

    See all (80) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol phospholipase C activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol phospholipase C activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoric diester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled dopamine receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chemotaxis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphatidylinositol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidylinositol-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of acetylcholine secretion, neurotransmission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of axon regeneration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of locomotion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to synapse IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of egg-laying behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of locomotion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of nematode pharyngeal pumping IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of nematode pharyngeal pumping IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in release of sequestered calcium ion into cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in thermotaxis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in adherens junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in anchoring junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perikaryon IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase;1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8;Phosphoinositide phospholipase C
    NP_001021346.1
    • Confirmed by transcript evidence
    NP_001021347.1
    • Confirmed by transcript evidence
    NP_001021348.1
    • Confirmed by transcript evidence
    NP_001300014.1
    • Confirmed by transcript evidence
    NP_001300016.1
    • Confirmed by transcript evidence
    NP_001300018.1
    • Confirmed by transcript evidence
    NP_001300020.1
    • Confirmed by transcript evidence
    NP_001300022.1
    • Confirmed by transcript evidence
    NP_001300024.1
    • Confirmed by transcript evidence
    NP_001300026.1
    • Confirmed by transcript evidence
    NP_001300028.1
    • Confirmed by transcript evidence
    NP_001300030.1
    • Confirmed by transcript evidence
    NP_001300032.1
    • Confirmed by transcript evidence
    NP_001300034.1
    • Confirmed by transcript evidence
    NP_001368552.1
    • Confirmed by transcript evidence
    NP_001368553.1
    • Confirmed by transcript evidence
    NP_001368554.1
    • Confirmed by transcript evidence
    NP_001368555.1
    • Confirmed by transcript evidence
    NP_001368556.1
    • Confirmed by transcript evidence
    NP_001368557.1
    • Confirmed by transcript evidence
    NP_001368558.1
    • Confirmed by transcript evidence
    NP_001368559.1
    • Confirmed by transcript evidence
    NP_001368560.1
    • Confirmed by transcript evidence
    NP_001380184.1
    • Confirmed by transcript evidence
    NP_001380185.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      20818..43704
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001313089.4 → NP_001300018.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AV83
      Conserved Domains (7) summary
      cd00275
      Location:789 → 909
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08591
      Location:339 → 755
      PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
      PLN02952
      Location:218 → 888
      PLN02952; phosphoinositide phospholipase C
      cd13361
      Location:17 → 142
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      pfam06631
      Location:1015 → 1057
      DUF1154; Protein of unknown function (DUF1154)
      pfam08703
      Location:1183 → 1324
      PLC-beta_C; PLC-beta C terminal
      pfam09279
      Location:249 → 335
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like

    2. NM_001380577.1 → NP_001368553.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3ARQ7
      Conserved Domains (7) summary
      cd00275
      Location:870 → 990
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08591
      Location:339 → 495
      PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
      cd13361
      Location:17 → 142
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      cd16200
      Location:147 → 327
      EFh_PI-PLCbeta; EF-hand motif found in metazoan phosphoinositide-specific phospholipase C (PI-PLC)-beta isozymes
      pfam06631
      Location:1096 → 1139
      DUF1154; Protein of unknown function (DUF1154)
      pfam08703
      Location:1252 → 1393
      PLC-beta_C; PLC-beta C terminal
      cl14615
      Location:733 → 836
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily

    3. NM_001392458.1 → NP_001380184.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AXI3
      Conserved Domains (6) summary
      cd00275
      Location:789 → 909
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08591
      Location:339 → 755
      PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
      cd13361
      Location:17 → 142
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      cd16200
      Location:147 → 327
      EFh_PI-PLCbeta; EF-hand motif found in metazoan phosphoinositide-specific phospholipase C (PI-PLC)-beta isozymes
      pfam06631
      Location:1015 → 1058
      DUF1154; Protein of unknown function (DUF1154)
      pfam08703
      Location:1171 → 1312
      PLC-beta_C; PLC-beta C terminal

    4. NM_001313091.3 → NP_001300020.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AS74
      Conserved Domains (7) summary
      cd00275
      Location:810 → 930
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08591
      Location:339 → 776
      PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
      PLN02952
      Location:218 → 909
      PLN02952; phosphoinositide phospholipase C
      cd13361
      Location:17 → 142
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      pfam06631
      Location:1036 → 1078
      DUF1154; Protein of unknown function (DUF1154)
      pfam08703
      Location:1204 → 1345
      PLC-beta_C; PLC-beta C terminal
      pfam09279
      Location:249 → 339
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like

    5. NM_001380579.1 → NP_001368555.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AV92
      Conserved Domains (5) summary
      cd08591
      Location:339 → 695
      PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
      PLN02228
      Location:205 → 840
      PLN02228; Phosphoinositide phospholipase C
      cd13361
      Location:17 → 142
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      pfam06631
      Location:955 → 998
      DUF1154; Protein of unknown function (DUF1154)
      pfam08703
      Location:1111 → 1252
      PLC-beta_C; PLC-beta C terminal

    6. NM_001313093.3 → NP_001300022.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3ARR2
      Conserved Domains (7) summary
      cd00275
      Location:729 → 849
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08591
      Location:339 → 695
      PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
      PLN02228
      Location:205 → 840
      PLN02228; Phosphoinositide phospholipase C
      cd13361
      Location:17 → 142
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      pfam06631
      Location:955 → 997
      DUF1154; Protein of unknown function (DUF1154)
      pfam08703
      Location:1123 → 1264
      PLC-beta_C; PLC-beta C terminal
      pfam09279
      Location:249 → 339
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like

    7. NM_001380581.2 → NP_001368557.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3ARR7
      Conserved Domains (8) summary
      cd00275
      Location:867 → 987
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08591
      Location:311 → 467
      PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
      cd13361
      Location:17 → 142
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      pfam05109
      Location:500 → 640
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      cd16200
      Location:147 → 299
      EFh_PI-PLCbeta; EF-hand motif found in metazoan phosphoinositide-specific phospholipase C (PI-PLC)-beta isozymes
      pfam06631
      Location:1093 → 1136
      DUF1154; Protein of unknown function (DUF1154)
      pfam08703
      Location:1249 → 1390
      PLC-beta_C; PLC-beta C terminal
      cl14615
      Location:730 → 833
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily

    8. NM_001026177.6 → NP_001021348.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021348.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EBH0
      Conserved Domains (3) summary
      cd08591
      Location:339 → 495
      PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
      cd13361
      Location:17 → 142
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      pfam09279
      Location:249 → 335
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like

    9. NM_001380578.2 → NP_001368554.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AUL7
      Conserved Domains (6) summary
      cd08591
      Location:339 → 776
      PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
      PLN02222
      Location:237 → 911
      PLN02222; phosphoinositide phospholipase C 2
      cd13361
      Location:17 → 142
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      cd16200
      Location:147 → 327
      EFh_PI-PLCbeta; EF-hand motif found in metazoan phosphoinositide-specific phospholipase C (PI-PLC)-beta isozymes
      pfam06631
      Location:1036 → 1079
      DUF1154; Protein of unknown function (DUF1154)
      pfam08703
      Location:1192 → 1333
      PLC-beta_C; PLC-beta C terminal

    10. NM_001380580.2 → NP_001368556.1  Phosphoinositide phospholipase C [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AS80
      Conserved Domains (8) summary
      cd00275
      Location:948 → 1068
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08591
      Location:311 → 467
      PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
      cd13361
      Location:17 → 142
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      pfam05109
      Location:500 → 640
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      cd16200
      Location:147 → 299
      EFh_PI-PLCbeta; EF-hand motif found in metazoan phosphoinositide-specific phospholipase C (PI-PLC)-beta isozymes
      pfam06631
      Location:1174 → 1217
      DUF1154; Protein of unknown function (DUF1154)
      pfam08703
      Location:1327 → 1471
      PLC-beta_C; PLC-beta C terminal
      cl14615
      Location:811 → 914
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily

    11. NM_001026175.5 → NP_001021346.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021346.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EBH0
      Conserved Domains (8) summary
      cd00275
      Location:895 → 1015
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08591
      Location:339 → 495
      PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
      PLN02952
      Location:218 → 994
      PLN02952; phosphoinositide phospholipase C
      cd13361
      Location:17 → 142
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      pfam06631
      Location:1121 → 1163
      DUF1154; Protein of unknown function (DUF1154)
      pfam08703
      Location:1277 → 1418
      PLC-beta_C; PLC-beta C terminal
      pfam09279
      Location:249 → 339
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
      cl14615
      Location:758 → 861
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily

    12. NM_001026176.3 → NP_001021347.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021347.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EBH0, Q6EZG7, Q95X30, Q9U6B9
      Conserved Domains (8) summary
      cd00275
      Location:895 → 1015
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08591
      Location:339 → 495
      PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
      PLN02952
      Location:218 → 994
      PLN02952; phosphoinositide phospholipase C
      cd13361
      Location:17 → 142
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      pfam06631
      Location:1121 → 1163
      DUF1154; Protein of unknown function (DUF1154)
      pfam08703
      Location:1289 → 1430
      PLC-beta_C; PLC-beta C terminal
      pfam09279
      Location:249 → 339
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
      cl14615
      Location:758 → 861
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily

    13. NM_001313087.3 → NP_001300016.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AUL3
      Conserved Domains (8) summary
      cd00275
      Location:870 → 990
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08591
      Location:339 → 495
      PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
      PLN02952
      Location:218 → 969
      PLN02952; phosphoinositide phospholipase C
      cd13361
      Location:17 → 142
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      pfam06631
      Location:1096 → 1138
      DUF1154; Protein of unknown function (DUF1154)
      pfam08703
      Location:1264 → 1405
      PLC-beta_C; PLC-beta C terminal
      pfam09279
      Location:249 → 339
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
      cl14615
      Location:733 → 836
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily

    14. NM_001313103.4 → NP_001300032.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3ARS4
      Conserved Domains (7) summary
      cd00275
      Location:782 → 902
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08591
      Location:311 → 748
      PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
      PLN02952
      Location:206 → 881
      PLN02952; phosphoinositide phospholipase C
      cd13361
      Location:17 → 142
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      pfam06631
      Location:1008 → 1050
      DUF1154; Protein of unknown function (DUF1154)
      pfam08703
      Location:1176 → 1317
      PLC-beta_C; PLC-beta C terminal
      pfam09279
      Location:221 → 311
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like

    15. NM_001380582.2 → NP_001368558.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AXJ6
      Conserved Domains (7) summary
      cd00275
      Location:842 → 962
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08591
      Location:311 → 467
      PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
      cd13361
      Location:17 → 142
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      cd16200
      Location:147 → 299
      EFh_PI-PLCbeta; EF-hand motif found in metazoan phosphoinositide-specific phospholipase C (PI-PLC)-beta isozymes
      pfam06631
      Location:1068 → 1111
      DUF1154; Protein of unknown function (DUF1154)
      pfam08703
      Location:1224 → 1365
      PLC-beta_C; PLC-beta C terminal
      cl14615
      Location:705 → 808
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily

    16. NM_001380583.1 → NP_001368559.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AUN1
      Conserved Domains (6) summary
      cd00275
      Location:761 → 881
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08591
      Location:311 → 727
      PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
      cd13361
      Location:17 → 142
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      cd16200
      Location:147 → 299
      EFh_PI-PLCbeta; EF-hand motif found in metazoan phosphoinositide-specific phospholipase C (PI-PLC)-beta isozymes
      pfam06631
      Location:987 → 1030
      DUF1154; Protein of unknown function (DUF1154)
      pfam08703
      Location:1143 → 1284
      PLC-beta_C; PLC-beta C terminal

    17. NM_001313095.4 → NP_001300024.1  Phosphoinositide phospholipase C [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AXJ0
      Conserved Domains (7) summary
      cd00275
      Location:948 → 1068
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08591
      Location:311 → 467
      PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
      cd13361
      Location:17 → 142
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      pfam06631
      Location:1174 → 1216
      DUF1154; Protein of unknown function (DUF1154)
      pfam08703
      Location:1342 → 1483
      PLC-beta_C; PLC-beta C terminal
      pfam09279
      Location:221 → 307
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
      cl14615
      Location:811 → 914
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily

    18. NM_001313085.3 → NP_001300014.1  Phosphoinositide phospholipase C [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AXH8
      Conserved Domains (7) summary
      cd00275
      Location:976 → 1096
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08591
      Location:339 → 495
      PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
      cd13361
      Location:17 → 142
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      pfam06631
      Location:1202 → 1244
      DUF1154; Protein of unknown function (DUF1154)
      pfam08703
      Location:1370 → 1511
      PLC-beta_C; PLC-beta C terminal
      pfam09279
      Location:249 → 339
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
      cl14615
      Location:839 → 942
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily

    19. NM_001380576.2 → NP_001368552.1  Phosphoinositide phospholipase C [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AS71
      Conserved Domains (8) summary
      cd00275
      Location:976 → 1096
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08591
      Location:339 → 495
      PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
      cd13361
      Location:17 → 142
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      pfam05109
      Location:528 → 668
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      cd16200
      Location:147 → 327
      EFh_PI-PLCbeta; EF-hand motif found in metazoan phosphoinositide-specific phospholipase C (PI-PLC)-beta isozymes
      pfam06631
      Location:1202 → 1245
      DUF1154; Protein of unknown function (DUF1154)
      pfam08703
      Location:1355 → 1499
      PLC-beta_C; PLC-beta C terminal
      cl14615
      Location:839 → 942
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily

    20. NM_001313097.3 → NP_001300026.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AUM3
      Conserved Domains (8) summary
      cd00275
      Location:867 → 987
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08591
      Location:311 → 467
      PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
      PLN02952
      Location:206 → 966
      PLN02952; phosphoinositide phospholipase C
      cd13361
      Location:17 → 142
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      pfam06631
      Location:1093 → 1135
      DUF1154; Protein of unknown function (DUF1154)
      pfam08703
      Location:1261 → 1402
      PLC-beta_C; PLC-beta C terminal
      pfam09279
      Location:221 → 307
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
      cl14615
      Location:730 → 833
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily

    21. NM_001313099.3 → NP_001300028.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AV97
      Conserved Domains (8) summary
      cd00275
      Location:842 → 962
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08591
      Location:311 → 467
      PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
      PLN02952
      Location:206 → 941
      PLN02952; phosphoinositide phospholipase C
      cd13361
      Location:17 → 142
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      pfam06631
      Location:1068 → 1110
      DUF1154; Protein of unknown function (DUF1154)
      pfam08703
      Location:1236 → 1377
      PLC-beta_C; PLC-beta C terminal
      pfam09279
      Location:221 → 307
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
      cl14615
      Location:705 → 808
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily

    22. NM_001313101.3 → NP_001300030.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AS85
      Conserved Domains (7) summary
      cd00275
      Location:761 → 881
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08591
      Location:311 → 727
      PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
      PLN02952
      Location:206 → 860
      PLN02952; phosphoinositide phospholipase C
      cd13361
      Location:17 → 142
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      pfam06631
      Location:987 → 1029
      DUF1154; Protein of unknown function (DUF1154)
      pfam08703
      Location:1155 → 1296
      PLC-beta_C; PLC-beta C terminal
      pfam09279
      Location:221 → 311
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like

    23. NM_001380584.1 → NP_001368560.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AVA5
      Conserved Domains (6) summary
      cd08591
      Location:311 → 748
      PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
      PLN02222
      Location:209 → 883
      PLN02222; phosphoinositide phospholipase C 2
      cd13361
      Location:17 → 142
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      cd16200
      Location:147 → 299
      EFh_PI-PLCbeta; EF-hand motif found in metazoan phosphoinositide-specific phospholipase C (PI-PLC)-beta isozymes
      pfam06631
      Location:1008 → 1051
      DUF1154; Protein of unknown function (DUF1154)
      pfam08703
      Location:1164 → 1305
      PLC-beta_C; PLC-beta C terminal

    24. NM_001313105.3 → NP_001300034.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AXK2
      Conserved Domains (7) summary
      cd00275
      Location:701 → 821
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08591
      Location:311 → 667
      PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
      PLN02228
      Location:218 → 812
      PLN02228; Phosphoinositide phospholipase C
      cd13361
      Location:17 → 142
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      pfam06631
      Location:927 → 969
      DUF1154; Protein of unknown function (DUF1154)
      pfam08703
      Location:1095 → 1236
      PLC-beta_C; PLC-beta C terminal
      pfam09279
      Location:221 → 311
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like

    25. NM_001392459.1 → NP_001380185.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AS90
      Conserved Domains (6) summary
      cd00275
      Location:701 → 821
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08591
      Location:311 → 667
      PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
      cd13361
      Location:17 → 142
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      cd16200
      Location:147 → 299
      EFh_PI-PLCbeta; EF-hand motif found in metazoan phosphoinositide-specific phospholipase C (PI-PLC)-beta isozymes
      pfam06631
      Location:927 → 970
      DUF1154; Protein of unknown function (DUF1154)
      pfam08703
      Location:1083 → 1224
      PLC-beta_C; PLC-beta C terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G5EBH0.1

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