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    lec-5 Galectin [ Caenorhabditis elegans ]

    Gene ID: 173992, updated on 9-Dec-2024

    Summary

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    Official Symbol
    lec-5
    Official Full Name
    Galectin
    Primary source
    WormBase:WBGene00002268
    Locus tag
    CELE_ZK1248.16
    See related
    AllianceGenome:WB:WBGene00002268
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable carbohydrate binding activity and galactoside binding activity. Located in membrane raft. Orthologous to human LGALS9 (galectin 9); LGALS9B (galectin 9B); and LGALS9C (galectin 9C). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See lec-5 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    6
    Sequence:
    Chromosome: II; NC_003280.10 (5839639..5841103, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene WW domain-containing protein Neighboring gene Protein LZIC Neighboring gene ncRNA Neighboring gene Peptidase M13 C-terminal domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The galectin LEC-5 is a novel binding partner for RAB-11. Zhang N, et al. Biochem Biophys Res Commun, 2018 Oct 28. PMID 30274774
    2. Cholesterol-responsive metabolic proteins are required for larval development in Caenorhabditis elegans. Kawasaki I, et al. Mol Cells, 2013 Nov. PMID 24218109, Free PMC Article
    3. Caenorhabditis elegans galectins LEC-1-LEC-11: structural features and sugar-binding properties. Nemoto-Sasaki Y, et al. Biochim Biophys Acta, 2008 Oct. PMID 18675319
    4. A Caenorhabditis elegans glycolipid-binding galectin functions in host defense against bacterial infection. Ideo H, et al. J Biol Chem, 2009 Sep 25. PMID 19635802, Free PMC Article
    5. An analysis of the Caenorhabditis elegans lipid raft proteome using geLC-MS/MS. Rao W, et al. J Proteomics, 2011 Feb 1. PMID 21070894

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Identification of galectin LEC-5 as a direct physical interactor of RAB-11.
      Title: The galectin LEC-5 is a novel binding partner for RAB-11.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables carbohydrate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables galactoside binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane raft HDA PubMed 

    General protein information

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    Preferred Names
    Galectin
    NP_495163.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      5839639..5841103 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_062762.11 → NP_495163.1  Galectin [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495163.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EFI4
      Conserved Domains (2) summary
      smart00276
      Location:42 → 170
      GLECT; Galectin
      cd00070
      Location:191 → 307
      GLECT; Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may ...
    Nucleotide Protein
    Heading Accession and Version

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