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    F35A5.8 BAR domain-containing protein;SH3 domain-containing GRB2-like protein B1 [ Caenorhabditis elegans ]

    Gene ID: 180667, updated on 9-Dec-2024

    Summary

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    Official Symbol
    F35A5.8
    Official Full Name
    BAR domain-containing protein;SH3 domain-containing GRB2-like protein B1
    Primary source
    WormBase:WBGene00001335
    Locus tag
    CELE_F35A5.8
    See related
    AllianceGenome:WB:WBGene00001335
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in membrane organization. Predicted to be located in cytoplasm. Predicted to be active in membrane. Is expressed in body wall musculature; nervous system; pharynx; and reproductive system. Orthologous to several human genes including SH3GLB2 (SH3 domain containing GRB2 like, endophilin B2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See F35A5.8 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    13
    Sequence:
    Chromosome: X; NC_003284.9 (3800035..3803464, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Activated in Blocked Unfolded protein response Neighboring gene ncRNA Neighboring gene Secreted protein Neighboring gene Titin-like

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A combined binary interaction and phenotypic map of C. elegans cell polarity proteins. Koorman T, et al. Nat Cell Biol, 2016 Mar. PMID 26780296, Free PMC Article
    2. SH3 interactome conserves general function over specific form. Xin X, et al. Mol Syst Biol, 2013. PMID 23549480, Free PMC Article
    3. A genome-wide study of PDZ-domain interactions in C. elegans reveals a high frequency of non-canonical binding. Lenfant N, et al. BMC Genomics, 2010 Nov 26. PMID 21110867, Free PMC Article
    4. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article
    5. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in membrane organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    BAR domain-containing protein;SH3 domain-containing GRB2-like protein B1
    NP_001263954.1
    • Confirmed by transcript evidence
    NP_741756.1
    • Confirmed by transcript evidence
    NP_741757.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      3800035..3803464 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001277025.4 → NP_001263954.1  SH3 domain-containing GRB2-like protein B1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001263954.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      L8E817
      Conserved Domains (2) summary
      cd07594
      Location:21 → 251
      BAR_Endophilin_B; The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-B
      cd11802
      Location:298 → 349
      SH3_Endophilin_B; Src homology 3 domain of Endophilin-B

    2. NM_171657.8 → NP_741756.1  SH3 domain-containing GRB2-like protein B1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741756.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q20005
      Conserved Domains (2) summary
      cd07594
      Location:21 → 264
      BAR_Endophilin_B; The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-B
      cd11802
      Location:311 → 362
      SH3_Endophilin_B; Src homology 3 domain of Endophilin-B

    3. NM_171658.5 → NP_741757.1  BAR domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741757.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8WT52
      Conserved Domains (1) summary
      cd07594
      Location:21 → 264
      BAR_Endophilin_B; The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-B
    Nucleotide Protein
    Heading Accession and Version

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