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    sqt-3 Collagen triple helix repeat protein;Cuticle collagen 1 [ Caenorhabditis elegans ]

    Gene ID: 179693, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sqt-3
    Official Full Name
    Collagen triple helix repeat protein;Cuticle collagen 1
    Primary source
    WormBase:WBGene00005018
    Locus tag
    CELE_F23H12.4
    See related
    AllianceGenome:WB:WBGene00005018
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be a structural constituent of cuticle. Involved in cuticle development involved in collagen and cuticulin-based cuticle molting cycle. Located in collagen and cuticulin-based cuticle extracellular matrix. Is expressed in hypodermis. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See sqt-3 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    3
    Sequence:
    Chromosome: V; NC_003283.11 (12352745..12354320)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene V-SNARE coiled-coil homology domain-containing protein Neighboring gene IncG Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene pseudo Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Caenorhabditis elegans sqt-3 mutants have mutations in the col-1 collagen gene. van der Keyl H, et al. Dev Dyn, 1994 Sep. PMID 7803850
    2. Caenorhabditis elegans morphogenesis: the role of the cytoskeleton in elongation of the embryo. Priess JR, et al. Dev Biol, 1986 Sep. PMID 3743895
    3. Haemonchus contortus: evidence that the 3A3 collagen gene is a member of an evolutionarily conserved family of nematode cuticle collagens. Cox GN, et al. Exp Parasitol, 1990 Feb. PMID 2404780
    4. Expression of chimeric genes in Caenorhabditis elegans. Jefferson RA, et al. J Mol Biol, 1987 Jan 5. PMID 3295256
    5. Structure and expression of Ascaris suum collagen genes: a comparison with Caenorhabditis elegans. Kingston IB, et al. Acta Trop, 1990 Jul. PMID 1978528

    See all (82) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. analysis of the roles of dpy-31, sqt-3, and dpy-17 in nematode collagen assembly
      Title: The C terminus of collagen SQT-3 has complex and essential functions in nematode collagen assembly.
    2. Suppressor of DPY-31. rol-4 is synonym.
      Title: Gene interactions in Caenorhabditis elegans define DPY-31 as a candidate procollagen C-proteinase and SQT-3/ROL-4 as its predicted major target.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables structural constituent of cuticle IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of cuticle NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in collagen and cuticulin-based cuticle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in collagen and cuticulin-based cuticle development NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in cuticle development involved in collagen and cuticulin-based cuticle molting cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in collagen and cuticulin-based cuticle extracellular matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of collagen trimer IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular region NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Collagen triple helix repeat protein;Cuticle collagen 1
    NP_001256412.1
    • Confirmed by transcript evidence
    NP_001256413.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      12352745..12354320
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001269483.3 → NP_001256412.1  Cuticle collagen 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256412.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P08124, Q19763
      Conserved Domains (1) summary
      smart01088
      Location:12 → 64
      Col_cuticle_N; Nematode cuticle collagen N-terminal domain

    2. NM_001269484.3 → NP_001256413.1  Collagen triple helix repeat protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256413.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2L2C4
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P08124.2

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