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    utx-1 JmjC domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 181110, updated on 9-Dec-2024

    Summary

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    Official Symbol
    utx-1
    Official Full Name
    JmjC domain-containing protein
    Primary source
    WormBase:WBGene00017046
    Locus tag
    CELE_D2021.1
    See related
    AllianceGenome:WB:WBGene00017046
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; chromatin DNA binding activity; and histone H3K27me2/H3K27me3 demethylase activity. Involved in cell fate specification and programmed cell death. Part of MLL3/4 complex. Is expressed in several structures, including germ line; gonad; intestine; pharynx; and tail. Human ortholog(s) of this gene implicated in several diseases, including Kabuki syndrome; Stolerman neurodevelopmental syndrome; gastrointestinal system cancer (multiple); lung carcinoma (multiple); and triple-receptor negative breast cancer. Orthologous to several human genes including KDM6A (lysine demethylase 6A) and UTY (ubiquitously transcribed tetratricopeptide repeat containing, Y-linked). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See utx-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    14
    Sequence:
    Chromosome: X; NC_003284.9 (8557146..8563238)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Acyl-CoA thioesterase-like C-terminal domain-containing protein;HotDog ACOT-type domain-containing protein Neighboring gene Palmitoyltransferase Neighboring gene JmjC domain-containing protein;Lysine-specific demethylase jmjd-3.1 Neighboring gene G_PROTEIN_RECEP_F1_2 domain-containing protein Neighboring gene ncRNA Neighboring gene Secreted protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Gene repression. H3K27me and PRC2 transmit a memory of repression across generations and during development. Gaydos LJ, et al. Science, 2014 Sep 19. PMID 25237104, Free PMC Article
    2. Crosstalk between aging and the epigenome. Vlaming H, et al. Epigenomics, 2012 Feb. PMID 22332652
    3. Catalytic-independent roles of UTX-1 in C. elegans development. Vandamme J, et al. Worm, 2013 Apr 1. PMID 24058866, Free PMC Article
    4. Increasing Notch signaling antagonizes PRC2-mediated silencing to promote reprograming of germ cells into neurons. Seelk S, et al. Elife, 2016 Sep 7. PMID 27602485, Free PMC Article
    5. Ancestral function of Inhibitors-of-kappaB regulates Caenorhabditis elegans development. Brena D, et al. Sci Rep, 2020 Sep 30. PMID 32999373, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. H3K27 modifiers regulate lifespan in C. elegans in a context-dependent manner.
      Title: H3K27 modifiers regulate lifespan in C. elegans in a context-dependent manner.
    2. These results demonstrate that H3K27me and PRC2 each contribute to epigenetically transmitting the memory of repression across generations and during development.
      Title: Gene repression. H3K27me and PRC2 transmit a memory of repression across generations and during development.
    3. these results demonstrate that UTX-1 is required for many aspects of nematode development; but, unexpectedly, this function is independent of its enzymatic activity
      Title: The C. elegans H3K27 demethylase UTX-1 is essential for normal development, independent of its enzymatic activity.
    4. progressive increases in gene expression and loss of H3K27me3 on insulin/IGF-1 signaling components are due, at least in part, to increased activity of the H3K27 demethylase UTX-1 during aging.
      Title: Histone demethylase UTX-1 regulates C. elegans life span by targeting the insulin/IGF-1 signaling pathway.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone H3K27me2/H3K27me3 demethylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone demethylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell fate specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in programmed cell death IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of MLL3/4 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of MLL3/4 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    JmjC domain-containing protein
    NP_001309685.1
    • Confirmed by transcript evidence
    NP_001309686.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      8557146..8563238
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001322627.4 → NP_001309686.1  JmjC domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A131MCP7
      Conserved Domains (6) summary
      smart00028
      Location:385 → 414
      TPR; Tetratricopeptide repeats
      pfam02373
      Location:874 → 982
      JmjC; JmjC domain, hydroxylase
      smart00558
      Location:840 → 904
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      sd00006
      Location:315 → 343
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:349 → 382
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:348 → 414
      TPR_11; TPR repeat

    2. NM_001322626.4 → NP_001309685.1  JmjC domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A131MBT2
      Conserved Domains (6) summary
      smart00028
      Location:390 → 419
      TPR; Tetratricopeptide repeats
      pfam02373
      Location:879 → 987
      JmjC; JmjC domain, hydroxylase
      smart00558
      Location:845 → 909
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      sd00006
      Location:315 → 348
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:354 → 387
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:353 → 419
      TPR_11; TPR repeat
    Nucleotide Protein
    Heading Accession and Version

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