psme-3 Proteasome activator PA28 C-terminal domain-containing protein;Proteasome activator complex subunit 3 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: psme-3
Official Full Name: Proteasome activator PA28 C-terminal domain-containing protein;Proteasome activator complex subunit 3
Primary source: WormBase:WBGene00013435
Locus tag: CELE_Y66D12A.9
See related: AllianceGenome:WB:WBGene00013435
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable endopeptidase activator activity. Predicted to be involved in positive regulation of endopeptidase activity; regulation of G1/S transition of mitotic cell cycle; and regulation of proteasomal protein catabolic process. Predicted to be part of proteasome activator complex. Predicted to be active in cytoplasm and nucleoplasm. Orthologous to human PSME3 (proteasome activator subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See psme-3 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 3

Sequence:: Chromosome: III; NC_003281.10 (11568137..11573343)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cold temperature extends longevity and prevents disease-related protein aggregation through PA28gamma-induced proteasomes.
Title: Cold temperature extends longevity and prevents disease-related protein aggregation through PA28γ-induced proteasomes.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables endopeptidase activator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in regulation of G1/S transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of proteasomal protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
part_of proteasome activator complex	IEA Inferred from Electronic Annotation more info
part_of proteasome complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Proteasome activator PA28 C-terminal domain-containing protein;Proteasome activator complex subunit 3

NP_001407530.1

Confirmed by transcript evidence

NP_499493.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

11568137..11573343

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_067092.8 → NP_499493.1 Proteasome activator complex subunit 3 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_499493.1

Status: REVIEWED

UniProtKB/TrEMBL

Q95PZ7

Conserved Domains (2) summary

pfam02251
Location:11 → 68

PA28_alpha; Proteasome activator pa28 alpha subunit

pfam02252
Location:105 → 246

PA28_beta; Proteasome activator pa28 beta subunit
NM_001420556.1 → NP_001407530.1 Proteasome activator PA28 C-terminal domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A8S4SQL6