mnp-1 Matrix non-peptidase homolog 1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: mnp-1
Official Full Name: Matrix non-peptidase homolog 1
Primary source: WormBase:WBGene00007139
Locus tag: CELE_B0285.7
See related: AllianceGenome:WB:WBGene00007139
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to be active in cytoplasm; extracellular space; and membrane. Is expressed in several structures, including body wall musculature; intestine; muscle cell; neuroblasts; and somatic gonad precursor. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See mnp-1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 8

Sequence:: Chromosome: III; NC_003281.10 (4356594..4364979)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The data suggest that MNP-1 is expressed in migrating muscle cells and localizes to the plasma membrane with the non-peptidase domain exposed to the extra-cellular environment.
Title: Muscle cell migrations of C. elegans are mediated by the alpha-integrin INA-1, Eph receptor VAB-1, and a novel peptidase homologue MNP-1.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

B0285.7 (e-PCR)
- UniSTS:306715

STS3-136 (e-PCR)
- UniSTS:241976

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
NOT enables metalloaminopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
NOT enables peptide binding	IBA Inferred from Biological aspect of Ancestor more info
NOT enables zinc ion binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
NOT involved_in peptide catabolic process	IBA Inferred from Biological aspect of Ancestor more info
NOT involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Matrix non-peptidase homolog 1

NP_497878.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

4356594..4364979

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_065477.6 → NP_497878.1 Matrix non-peptidase homolog 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_497878.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P46557

Conserved Domains (2) summary

pfam01433
Location:172 → 556

Peptidase_M1; Peptidase family M1

cl14813
Location:294 → 480

GluZincin; Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)