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    duo-3 OTU domain-containing protein;USP domain-containing protein;Ubiquitin carboxyl-terminal hydrolase [ Caenorhabditis elegans ]

    Gene ID: 172925, updated on 9-Dec-2024

    Summary

    Official Symbol
    duo-3
    Official Full Name
    OTU domain-containing protein;USP domain-containing protein;Ubiquitin carboxyl-terminal hydrolase
    Primary source
    WormBase:WBGene00001112
    Locus tag
    CELE_Y106G6H.12
    See related
    AllianceGenome:WB:WBGene00001112
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable cysteine-type deubiquitinase activity. Predicted to be involved in protein deubiquitination. Orthologous to human USP29 (ubiquitin specific peptidase 29). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See duo-3 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    11
    Sequence:
    Chromosome: I; NC_003279.8 (10464289..10471056, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene F-box domain-containing protein Neighboring gene pseudo Neighboring gene Reverse transcriptase domain-containing protein Neighboring gene Osteoclast-stimulating factor 1

    Interactions

    General gene information

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity  
    enables cysteine-type deubiquitinase activity  
    enables hydrolase activity  

    General protein information

    Preferred Names
    OTU domain-containing protein;USP domain-containing protein;Ubiquitin carboxyl-terminal hydrolase
    NP_001293463.1
    • Confirmed by transcript evidence
    NP_001293464.1
    • Confirmed by transcript evidence
    NP_001293465.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      10464289..10471056 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001306534.2NP_001293463.1  Ubiquitin carboxyl-terminal hydrolase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293463.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PBM0
      Conserved Domains (3) summary
      cd02673
      Location:303554
      Peptidase_C19Q; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cl02553
      Location:812922
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      cl19932
      Location:669786
      OTU; OTU-like cysteine protease
    2. NM_001306535.3NP_001293464.1  USP domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293464.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PBZ5
      Conserved Domains (3) summary
      cd02673
      Location:148399
      Peptidase_C19Q; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cl02553
      Location:657767
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      cl19932
      Location:514631
      OTU; OTU-like cysteine protease
    3. NM_001306536.3NP_001293465.1  OTU domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293465.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PMF4
      Conserved Domains (3) summary
      cd02673
      Location:79238
      Peptidase_C19Q; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cl02553
      Location:496606
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      cl19932
      Location:353470
      OTU; OTU-like cysteine protease
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