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    arx-3 Actin-related protein 2/3 complex subunit [ Caenorhabditis elegans ]

    Gene ID: 3565442, updated on 9-Dec-2024

    Summary

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    Official Symbol
    arx-3
    Official Full Name
    Actin-related protein 2/3 complex subunit
    Primary source
    WormBase:WBGene00000201
    Locus tag
    CELE_Y79H2A.6
    See related
    AllianceGenome:WB:WBGene00000201
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable actin filament binding activity. Predicted to be involved in Arp2/3 complex-mediated actin nucleation. Predicted to be located in actin cytoskeleton and cytoplasm. Predicted to be part of Arp2/3 protein complex. Human ortholog(s) of this gene implicated in gastritis; immunodeficiency 71; myelodysplastic syndrome; and pancreatic cancer. Orthologous to human ARPC1A (actin related protein 2/3 complex subunit 1A) and ARPC1B (actin related protein 2/3 complex subunit 1B). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See arx-3 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    9
    Sequence:
    Chromosome: III; NC_003281.10 (12052424..12058458, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene MARVEL domain-containing protein Neighboring gene C2H2-type domain-containing protein Neighboring gene RRM domain-containing protein Neighboring gene Serine/threonine-protein kinase zyg-8;non-specific serine/threonine protein kinase Neighboring gene Homeobox protein php-3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A Caenorhabditis elegans nck-1 and filamentous actin-regulating protein pathway mediates a key cellular defense against bacterial pore-forming proteins. Sitaram A, et al. PLoS Pathog, 2022 Nov. PMID 36374839, Free PMC Article
    2. Forgetting is regulated via Musashi-mediated translational control of the Arp2/3 complex. Hadziselimovic N, et al. Cell, 2014 Mar 13. PMID 24630719
    3. Guanine nucleotide exchange factor OSG-1 confers functional aging via dysregulated Rho signaling in Caenorhabditis elegans neurons. Duan Z, et al. Genetics, 2015 Feb. PMID 25527286, Free PMC Article
    4. Chiral forces organize left-right patterning in C. elegans by uncoupling midline and anteroposterior axis. Pohl C, et al. Dev Cell, 2010 Sep 14. PMID 20833362, Free PMC Article
    5. Essential role of the C. elegans Arp2/3 complex in cell migration during ventral enclosure. Sawa M, et al. J Cell Sci, 2003 Apr 15. PMID 12640035

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in Arp2/3 complex-mediated actin nucleation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Arp2/3 complex-mediated actin nucleation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Arp2/3 protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Arp2/3 protein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Actin-related protein 2/3 complex subunit
    NP_001355516.1
    • Partially confirmed by transcript evidence
    NP_499570.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      12052424..12058458 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_067169.7 → NP_499570.1  Actin-related protein 2/3 complex subunit [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499570.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U1R7
      Conserved Domains (3) summary
      COG2319
      Location:15 → 274
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:17 → 56
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:50 → 272
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. NM_001368436.4 → NP_001355516.1  Actin-related protein 2/3 complex subunit [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A3P6PCS5
      Conserved Domains (3) summary
      sd00039
      Location:17 → 56
      7WD40; WD40 repeat [structural motif]
      pfam12894
      Location:15 → 67
      ANAPC4_WD40; Anaphase-promoting complex subunit 4 WD40 domain
      cl29593
      Location:50 → 272
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version

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