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    mag-1 Protein mago nashi homolog [ Caenorhabditis elegans ]

    Gene ID: 173073, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mag-1
    Official Full Name
    Protein mago nashi homolog
    Primary source
    WormBase:WBGene00003123
    Locus tag
    CELE_R09B3.5
    See related
    AllianceGenome:WB:WBGene00003123
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in several processes, including feminization of hermaphroditic germ-line; positive regulation of egg-laying behavior; and positive regulation of oogenesis. Predicted to be located in nucleus. Predicted to be part of catalytic step 2 spliceosome and exon-exon junction complex. Is expressed in head; pharynx; and tail. Orthologous to human MAGOHB (mago homolog B, exon junction complex subunit) and MAGOH (mago homolog, exon junction complex subunit). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See mag-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    2
    Sequence:
    Chromosome: I; NC_003279.8 (11912005..11912677, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene RRM domain-containing protein Neighboring gene RRM domain-containing protein Neighboring gene NEDD8-conjugating enzyme ubc-12 Neighboring gene Histone deacetylase Neighboring gene Farnesyl pyrophosphate synthase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. PIE-1 Translation in the Germline Lineage Contributes to PIE-1 Asymmetry in the Early Caenorhabditis elegans Embryo. Gauvin TJ, et al. G3 (Bethesda), 2018 Dec 10. PMID 30279189, Free PMC Article
    2. Ce-Y14 and MAG-1, components of the exon-exon junction complex, are required for embryogenesis and germline sexual switching in Caenorhabditis elegans. Kawano T, et al. Mech Dev, 2004 Jan. PMID 14706697
    3. Studies on reproductive stress caused by candidate Gram positive and Gram negative bacteria using model organism, Caenorhabditis elegans. Sharika R, et al. Gene, 2018 Apr 5. PMID 29382573
    4. A specific set of exon junction complex subunits is required for the nuclear retention of unspliced RNAs in Caenorhabditis elegans. Shiimori M, et al. Mol Cell Biol, 2013 Jan. PMID 23149939, Free PMC Article
    5. The mago nashi locus encodes an essential product required for germ plasm assembly in Drosophila. Newmark PA, et al. Development, 1994 May. PMID 8026338

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA splicing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in feminization of hermaphroditic germ-line IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nuclear mRNA surveillance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of egg-laying behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of oogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of exon-exon junction complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of exon-exon junction complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Protein mago nashi homolog
    NP_493025.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      11912005..11912677 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_060624.9 → NP_493025.1  Protein mago nashi homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_493025.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A023T4K3, O16104, O45714, P49029
      Conserved Domains (1) summary
      cd11295
      Location:10 → 152
      Mago_nashi; Mago nashi proteins, integral members of the exon junction complex
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P49029.2

    Gene LinkOut

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