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    Vim vimentin [ Mus musculus (house mouse) ]

    Gene ID: 22352, updated on 7-Jan-2025

    Summary

    Official Symbol
    Vimprovided by MGI
    Official Full Name
    vimentinprovided by MGI
    Primary source
    MGI:MGI:98932
    See related
    Ensembl:ENSMUSG00000026728 AllianceGenome:MGI:98932
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables RNA binding activity. A structural constituent of cytoskeleton and structural constituent of eye lens. Involved in intermediate filament organization and positive regulation of gene expression. Acts upstream of or within several processes, including astrocyte differentiation; cellular response to type II interferon; and lens fiber cell development. Located in several cellular components, including cell leading edge; intermediate filament; and phagocytic vesicle. Is expressed in several structures, including alimentary system; brain; genitourinary system; heart; and sensory organ. Used to study cataract 30. Human ortholog(s) of this gene implicated in atherosclerosis; autoimmune disease (multiple); and cataract 30. Orthologous to human VIM (vimentin). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Broad expression in subcutaneous fat pad adult (RPKM 622.6), mammary gland adult (RPKM 524.7) and 24 other tissues See more
    Orthologs
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    Genomic context

    See Vim in Genome Data Viewer
    Location:
    2 A1; 2 10.04 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (13579122..13587637)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (13574311..13582826)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_03709 Neighboring gene predicted gene, 54102 Neighboring gene predicted gene 9875 Neighboring gene ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 Neighboring gene STARR-seq mESC enhancer starr_03712 Neighboring gene STARR-seq mESC enhancer starr_03715 Neighboring gene STARR-positive B cell enhancer ABC_E3359 Neighboring gene STARR-positive B cell enhancer ABC_E10082 Neighboring gene STARR-positive B cell enhancer ABC_E7793 Neighboring gene STARR-seq mESC enhancer starr_03717 Neighboring gene STARR-seq mESC enhancer starr_03718 Neighboring gene STARR-seq mESC enhancer starr_03719 Neighboring gene STARR-seq mESC enhancer starr_03720 Neighboring gene STARR-seq mESC enhancer starr_03721 Neighboring gene 3-hydroxyacyl-CoA dehydratase 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • MGC102095

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding PubMed 
    enables double-stranded RNA binding PubMed 
    enables identical protein binding  
    enables identical protein binding  
    enables keratin filament binding  
    enables keratin filament binding  
    enables kinase binding  
    enables molecular adaptor activity  
    enables protein binding PubMed 
    enables protein domain specific binding  
    enables protein domain specific binding  
    enables protein phosphatase 2A binding  
    enables protein tyrosine kinase binding  
    enables scaffold protein binding  
    enables scaffold protein binding  
    enables structural constituent of cytoskeleton  
    enables structural constituent of cytoskeleton PubMed 
    enables structural constituent of cytoskeleton  
    enables structural constituent of eye lens PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within Bergmann glial cell differentiation PubMed 
    acts_upstream_of_or_within astrocyte development PubMed 
    involved_in cellular response to lipopolysaccharide  
    involved_in cellular response to lipopolysaccharide  
    involved_in cellular response to muramyl dipeptide  
    involved_in cellular response to muramyl dipeptide  
    acts_upstream_of_or_within cellular response to type II interferon PubMed 
    involved_in intermediate filament organization  
    acts_upstream_of_or_within intermediate filament organization PubMed 
    involved_in intermediate filament organization PubMed 
    acts_upstream_of_or_within intermediate filament-based process PubMed 
    acts_upstream_of_or_within lens fiber cell development PubMed 
    acts_upstream_of_or_within negative regulation of neuron projection development PubMed 
    acts_upstream_of neuron projection development PubMed 
    involved_in positive regulation of collagen biosynthetic process  
    involved_in positive regulation of collagen biosynthetic process  
    involved_in positive regulation of epithelial cell migration  
    involved_in positive regulation of gene expression PubMed 
    involved_in positive regulation of glial cell proliferation  
    involved_in regulation of Schwann cell migration  
    involved_in regulation of axonogenesis  
    involved_in regulation of mRNA stability  
    involved_in regulation of mRNA stability  
    Items 1 - 20 of 25
    Component Evidence Code Pubs
    is_active_in axon  
    located_in axon  
    located_in cell body  
    located_in cell leading edge PubMed 
    located_in cell projection PubMed 
    located_in cell projection  
    is_active_in cytoplasm  
    located_in cytoplasm PubMed 
    located_in cytoplasm  
    located_in cytoskeleton PubMed 
    located_in cytosol  
    located_in cytosol  
    is_active_in intermediate filament  
    located_in intermediate filament PubMed 
    located_in intermediate filament  
    located_in intermediate filament cytoskeleton  
    located_in neuron projection PubMed 
    located_in nuclear matrix  
    located_in perinuclear region of cytoplasm  
    located_in peroxisome  
    located_in peroxisome  
    located_in phagocytic vesicle PubMed 
    is_active_in plasma membrane  
    located_in plasma membrane PubMed 
    located_in type III intermediate filament PubMed 
    Items 1 - 20 of 25

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011701.4NP_035831.2  vimentin

      See identical proteins and their annotated locations for NP_035831.2

      Status: VALIDATED

      Source sequence(s)
      AK133726
      Consensus CDS
      CCDS15696.1
      UniProtKB/Swiss-Prot
      O08704, P20152, Q8CCH1
      UniProtKB/TrEMBL
      Q3U6S1, Q3V2S4, Q5FWJ3
      Related
      ENSMUSP00000028062.3, ENSMUST00000028062.8
      Conserved Domains (2) summary
      pfam00038
      Location:102410
      Filament; Intermediate filament protein
      pfam04732
      Location:14101
      Filament_head; Intermediate filament head (DNA binding) region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      13579122..13587637
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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