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    Ilk integrin linked kinase [ Mus musculus (house mouse) ]

    Gene ID: 16202, updated on 13-Jan-2025

    Summary

    Official Symbol
    Ilkprovided by MGI
    Official Full Name
    integrin linked kinaseprovided by MGI
    Primary source
    MGI:MGI:1195267
    See related
    Ensembl:ENSMUSG00000030890 AllianceGenome:MGI:1195267
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ILK-1; ILK-2; ESTM24; p59ILK
    Summary
    Predicted to enable several functions, including ATP binding activity; SH3 domain binding activity; and magnesium ion binding activity. Involved in several processes, including caveola assembly; positive regulation of BMP signaling pathway; and positive regulation of osteoblast differentiation. Acts upstream of or within several processes, including branching involved in ureteric bud morphogenesis; nervous system development; and phosphatidylinositol 3-kinase/protein kinase B signal transduction. Located in focal adhesion and lamellipodium. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and retina. Used to study dilated cardiomyopathy. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human ILK (integrin linked kinase). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Ubiquitous expression in bladder adult (RPKM 143.4), subcutaneous fat pad adult (RPKM 90.0) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Ilk in Genome Data Viewer
    Location:
    7 E3; 7 55.97 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (105385797..105392132)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (105736590..105742925)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene translocase of inner mitochondrial membrane 10B Neighboring gene predicted gene, 22504 Neighboring gene dynein heavy chain domain 1 Neighboring gene mitochondrial ribosomal protein S36, pseudogene 2 Neighboring gene STARR-positive B cell enhancer mm9_chr7:112892770-112893071 Neighboring gene ribosomal RNA processing 8 Neighboring gene STARR-positive B cell enhancer mm9_chr7:112900636-112900937 Neighboring gene TATA-box binding protein associated factor 10 Neighboring gene tripeptidyl peptidase I Neighboring gene dachsous cadherin related 1 Neighboring gene predicted gene, 57787

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Gene trapped (1) 
    • Targeted (15)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding  
    enables SH3 domain binding  
    enables integrin binding  
    enables integrin binding  
    enables magnesium ion binding  
    enables protein binding PubMed 
    enables protein domain specific binding  
    enables protein kinase activity  
    enables protein kinase binding  
    enables protein kinase binding  
    enables protein serine/threonine kinase activity  
    NOT enables protein serine/threonine kinase activity  
    enables protein-containing complex binding  
    enables protein-macromolecule adaptor activity  
    enables signaling receptor binding  
    Items 1 - 25 of 65
    Process Evidence Code Pubs
    acts_upstream_of_or_within Schwann cell development PubMed 
    acts_upstream_of_or_within branching involved in ureteric bud morphogenesis PubMed 
    involved_in caveola assembly PubMed 
    involved_in cell differentiation  
    involved_in cell morphogenesis  
    acts_upstream_of_or_within cell morphogenesis  
    acts_upstream_of cell population proliferation PubMed 
    acts_upstream_of_or_within cell projection organization PubMed 
    involved_in cell-matrix adhesion  
    acts_upstream_of_or_within establishment or maintenance of epithelial cell apical/basal polarity PubMed 
    acts_upstream_of_or_within fibroblast migration PubMed 
    involved_in integrin-mediated signaling pathway  
    acts_upstream_of_or_within integrin-mediated signaling pathway PubMed 
    involved_in integrin-mediated signaling pathway  
    involved_in mitotic spindle organization  
    involved_in myelin assembly  
    acts_upstream_of_or_within myelination in peripheral nervous system PubMed 
    involved_in negative regulation of apoptotic process  
    involved_in negative regulation of cardiac muscle cell apoptotic process  
    acts_upstream_of_or_within negative regulation of neural precursor cell proliferation PubMed 
    acts_upstream_of_or_within negative regulation of neural precursor cell proliferation PubMed 
    involved_in negative regulation of neuron apoptotic process  
    involved_in negative regulation of smooth muscle cell migration  
    involved_in negative regulation of smooth muscle cell proliferation  
    acts_upstream_of_or_within nerve development PubMed 
    acts_upstream_of neural precursor cell proliferation PubMed 
    acts_upstream_of neural precursor cell proliferation PubMed 
    involved_in neuron projection morphogenesis  
    involved_in outflow tract morphogenesis PubMed 
    acts_upstream_of_or_within peptidyl-serine phosphorylation PubMed 
    acts_upstream_of_or_within phosphatidylinositol 3-kinase/protein kinase B signal transduction PubMed 
    involved_in positive regulation of BMP signaling pathway PubMed 
    involved_in positive regulation of DNA-templated transcription  
    involved_in positive regulation of DNA-templated transcription  
    involved_in positive regulation of MAPK cascade  
    involved_in positive regulation of axon extension  
    involved_in positive regulation of axonogenesis  
    involved_in positive regulation of canonical NF-kappaB signal transduction  
    involved_in positive regulation of canonical NF-kappaB signal transduction  
    involved_in positive regulation of canonical Wnt signaling pathway  
    involved_in positive regulation of canonical Wnt signaling pathway  
    involved_in positive regulation of cell migration  
    acts_upstream_of_or_within positive regulation of cell population proliferation PubMed 
    involved_in positive regulation of cell population proliferation  
    involved_in positive regulation of cell-matrix adhesion  
    involved_in positive regulation of cellular senescence  
    involved_in positive regulation of dendrite morphogenesis  
    involved_in positive regulation of myoblast differentiation  
    involved_in positive regulation of osteoblast differentiation PubMed 
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    involved_in positive regulation of phosphorylation  
    involved_in positive regulation of protein phosphorylation  
    involved_in positive regulation of signal transduction  
    involved_in positive regulation of substrate adhesion-dependent cell spreading  
    involved_in positive regulation of substrate adhesion-dependent cell spreading  
    involved_in protein localization to cell cortex PubMed 
    involved_in protein phosphorylation  
    involved_in regulation of actin cytoskeleton organization  
    involved_in regulation of cell growth  
    involved_in substrate adhesion-dependent cell spreading  
    involved_in substrate adhesion-dependent cell spreading  
    involved_in substrate adhesion-dependent cell spreading  
    involved_in supramolecular fiber organization  
    involved_in tumor necrosis factor-mediated signaling pathway  
    involved_in tumor necrosis factor-mediated signaling pathway  
    Items 1 - 25 of 65
    Items 1 - 20 of 22
    Component Evidence Code Pubs
    located_in axon  
    located_in cell cortex  
    located_in cell-cell junction  
    located_in centrosome  
    located_in chromatin  
    located_in costamere  
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in cytosol  
    located_in cytosol  
    located_in dendritic shaft  
    is_active_in focal adhesion  
    located_in focal adhesion PubMed 
    located_in focal adhesion PubMed 
    located_in lamellipodium PubMed 
    located_in neuronal cell body  
    located_in nucleus  
    located_in plasma membrane  
    part_of protein-containing complex  
    located_in sarcomere  
    located_in stress fiber  
    located_in terminal bouton  
    Items 1 - 20 of 22

    General protein information

    Preferred Names
    scaffold protein ILK
    Names
    59 kDa serine/threonine-protein kinase
    beta-integrin-linked kinase
    inactive integrin-linked kinase
    integrin binding protein kinase
    integrin-linked protein kinase
    NP_001155196.1
    NP_034692.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001161724.1NP_001155196.1  scaffold protein ILK

      See identical proteins and their annotated locations for NP_001155196.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC121823, AK002344, AK011766, CA752166, CK625497
      Consensus CDS
      CCDS21659.1
      UniProtKB/Swiss-Prot
      O55222, Q78KK2
      Related
      ENSMUSP00000033182.4, ENSMUST00000033182.10
      Conserved Domains (4) summary
      cd14057
      Location:198449
      PK_ILK; Pseudokinase domain of Integrin Linked Kinase
      sd00045
      Location:3364
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:454
      Ank_4; Ankyrin repeats (many copies)
      pfam12796
      Location:38124
      Ank_2; Ankyrin repeats (3 copies)
    2. NM_010562.2NP_034692.2  scaffold protein ILK

      See identical proteins and their annotated locations for NP_034692.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC121823
      Consensus CDS
      CCDS21659.1
      UniProtKB/Swiss-Prot
      O55222, Q78KK2
      Related
      ENSMUSP00000130341.2, ENSMUST00000163389.9
      Conserved Domains (4) summary
      cd14057
      Location:198449
      PK_ILK; Pseudokinase domain of Integrin Linked Kinase
      sd00045
      Location:3364
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:454
      Ank_4; Ankyrin repeats (many copies)
      pfam12796
      Location:38124
      Ank_2; Ankyrin repeats (3 copies)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      105385797..105392132
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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