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    Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide [ Mus musculus (house mouse) ]

    Gene ID: 22627, updated on 4-Jan-2025

    Summary

    Official Symbol
    Ywhaeprovided by MGI
    Official Full Name
    tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptideprovided by MGI
    Primary source
    MGI:MGI:894689
    See related
    Ensembl:ENSMUSG00000020849 AllianceGenome:MGI:894689
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables protein domain specific binding activity; protein phosphatase binding activity; and protein phosphatase inhibitor activity. Acts upstream of or within neuron migration; pallium development; and protein targeting. Located in cytoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Used to study Miller-Dieker lissencephaly syndrome and left ventricular noncompaction. Orthologous to human YWHAE (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Broad expression in CNS E11.5 (RPKM 424.9), CNS E18 (RPKM 417.5) and 25 other tissues See more
    Orthologs
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    Genomic context

    See Ywhae in Genome Data Viewer
    Location:
    11 B5; 11 45.92 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (75620121..75656667)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (75732887..75765841)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3975 Neighboring gene myosin IC Neighboring gene STARR-positive B cell enhancer ABC_E7018 Neighboring gene v-crk avian sarcoma virus CT10 oncogene homolog Neighboring gene STARR-positive B cell enhancer ABC_E3001 Neighboring gene STARR-positive B cell enhancer ABC_E8425 Neighboring gene predicted gene, 57767 Neighboring gene STARR-seq mESC enhancer starr_30005 Neighboring gene STARR-positive B cell enhancer ABC_E5247 Neighboring gene double C2, beta Neighboring gene STARR-seq mESC enhancer starr_30008 Neighboring gene predicted gene 12339 Neighboring gene rabphilin 3A-like (without C2 domains)

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (5)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by MGI

    Items 1 - 25 of 31
    Function Evidence Code Pubs
    enables calcium channel inhibitor activity  
    enables calcium channel inhibitor activity  
    enables calcium channel regulator activity  
    enables enzyme binding  
    enables histone deacetylase binding  
    enables histone deacetylase binding  
    enables identical protein binding  
    enables identical protein binding  
    enables phosphoprotein binding  
    enables phosphoserine residue binding  
    enables phosphoserine residue binding  
    enables phosphoserine residue binding  
    enables potassium channel regulator activity  
    enables potassium channel regulator activity  
    enables protein binding PubMed 
    enables protein domain specific binding PubMed 
    enables protein heterodimerization activity  
    enables protein heterodimerization activity  
    enables protein phosphatase binding PubMed 
    enables protein phosphatase inhibitor activity PubMed 
    enables protein sequestering activity  
    enables protein sequestering activity  
    enables protein-containing complex binding  
    enables scaffold protein binding  
    enables scaffold protein binding  
    enables signaling adaptor activity  
    enables signaling adaptor activity  
    enables transmembrane transporter binding  
    enables transmembrane transporter binding  
    enables ubiquitin protein ligase binding  
    enables ubiquitin protein ligase binding  
    Items 1 - 25 of 31
    Items 1 - 25 of 35
    Process Evidence Code Pubs
    involved_in MAPK cascade  
    involved_in MAPK cascade  
    involved_in cellular response to heat  
    involved_in cellular response to heat  
    acts_upstream_of_or_within cerebral cortex development PubMed 
    involved_in cytoplasmic pattern recognition receptor signaling pathway  
    involved_in cytoplasmic pattern recognition receptor signaling pathway  
    involved_in cytoplasmic sequestering of protein  
    involved_in cytoplasmic sequestering of protein  
    acts_upstream_of_or_within hippocampus development PubMed 
    involved_in negative regulation of calcium ion export across plasma membrane  
    involved_in negative regulation of calcium ion export across plasma membrane  
    involved_in negative regulation of toll-like receptor signaling pathway  
    involved_in negative regulation of toll-like receptor signaling pathway  
    acts_upstream_of_or_within neuron migration PubMed 
    acts_upstream_of_or_within neuron migration PubMed 
    involved_in positive regulation of hippo signaling  
    involved_in positive regulation of hippo signaling  
    involved_in positive regulation of protein export from nucleus  
    involved_in positive regulation of protein export from nucleus  
    involved_in protein localization  
    involved_in protein localization to endoplasmic reticulum  
    involved_in protein localization to endoplasmic reticulum  
    involved_in protein localization to nucleus  
    involved_in protein localization to nucleus  
    acts_upstream_of_or_within protein targeting PubMed 
    involved_in regulation of cytosolic calcium ion concentration  
    involved_in regulation of cytosolic calcium ion concentration  
    involved_in regulation of membrane repolarization  
    involved_in regulation of membrane repolarization  
    involved_in regulation of mitotic cell cycle  
    involved_in regulation of postsynaptic membrane neurotransmitter receptor levels  
    involved_in regulation of potassium ion transmembrane transport  
    involved_in regulation of potassium ion transmembrane transporter activity  
    involved_in signal transduction  
    Items 1 - 25 of 35
    Component Evidence Code Pubs
    located_in axon  
    located_in central region of growth cone  
    is_active_in cytoplasm  
    located_in cytoplasm PubMed 
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in cytoplasm  
    located_in cytosol  
    located_in cytosol  
    located_in endoplasmic reticulum  
    is_active_in endoplasmic reticulum  
    is_active_in glutamatergic synapse  
    part_of kinesin complex  
    located_in melanosome  
    located_in mitochondrion PubMed 
    located_in nucleus  
    located_in nucleus  
    located_in plasma membrane  
    colocalizes_with plasma membrane  
    is_active_in synapse  

    General protein information

    Preferred Names
    14-3-3 protein epsilon
    Names
    14-3-3 epsilon
    14-3-3E
    tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activatioprotein, epsilon polypeptide

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009536.4NP_033562.3  14-3-3 protein epsilon

      See identical proteins and their annotated locations for NP_033562.3

      Status: VALIDATED

      Source sequence(s)
      AK135831, BC058686, BY293945
      Consensus CDS
      CCDS25056.1
      UniProtKB/Swiss-Prot
      P62259
      UniProtKB/TrEMBL
      Q5SS40, Q8BPH1
      Related
      ENSMUSP00000070993.4, ENSMUST00000067664.10
      Conserved Domains (1) summary
      cd10020
      Location:4233
      14-3-3_epsilon; 14-3-3 epsilon, an isoform of 14-3-3 protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      75620121..75656667
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036156631.1XP_036012524.1  14-3-3 protein epsilon isoform X1

      UniProtKB/TrEMBL
      Q8BPH1
      Conserved Domains (1) summary
      cd10020
      Location:4233
      14-3-3_epsilon; 14-3-3 epsilon, an isoform of 14-3-3 protein
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