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    Kcnj5 potassium inwardly-rectifying channel, subfamily J, member 5 [ Mus musculus (house mouse) ]

    Gene ID: 16521, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Kcnj5provided by MGI
    Official Full Name
    potassium inwardly-rectifying channel, subfamily J, member 5provided by MGI
    Primary source
    MGI:MGI:104755
    See related
    Ensembl:ENSMUSG00000032034 AllianceGenome:MGI:104755
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CIR; GIRK4; KATP-1; Kir3.4
    Summary
    Predicted to enable inward rectifier potassium channel activity and voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization. Predicted to be involved in cardiac conduction; potassium ion import across plasma membrane; and regulation of monoatomic ion transmembrane transport. Predicted to be located in T-tubule and external side of plasma membrane. Predicted to be part of I(KACh) inward rectifier potassium channel complex. Predicted to be active in plasma membrane. Is expressed in several structures, including central nervous system; genitourinary system; heart; intestine; and liver lobe. Human ortholog(s) of this gene implicated in atrial fibrillation; long QT syndrome 13; and primary hyperaldosteronism. Orthologous to human KCNJ5 (potassium inwardly rectifying channel subfamily J member 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in heart adult (RPKM 14.0), liver E14 (RPKM 0.9) and 1 other tissue See more
    Orthologs
    human all
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    Genomic context

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    See Kcnj5 in Genome Data Viewer
    Location:
    9 A4; 9 17.65 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (32226002..32255640, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (32314706..32344380, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein 32 Neighboring gene 60S ribosomal protein L21 pseudogene Neighboring gene STARR-seq mESC enhancer starr_23720 Neighboring gene 60S ribosomal protein L21 pseudogene Neighboring gene STARR-seq mESC enhancer starr_23722 Neighboring gene STARR-seq mESC enhancer starr_23724 Neighboring gene STARR-seq mESC enhancer starr_23725 Neighboring gene STARR-positive B cell enhancer ABC_E9755 Neighboring gene STARR-positive B cell enhancer mm9_chr9:32094558-32094858 Neighboring gene STARR-positive B cell enhancer mm9_chr9:32157923-32158223 Neighboring gene STARR-positive B cell enhancer ABC_E38 Neighboring gene STARR-seq mESC enhancer starr_23730 Neighboring gene STARR-seq mESC enhancer starr_23731 Neighboring gene predicted gene, 39317 Neighboring gene predicted gene, 31755 Neighboring gene potassium inwardly-rectifying channel, subfamily J, member 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Genetic Ablation of G Protein-Gated Inwardly Rectifying K(+) Channels Prevents Training-Induced Sinus Bradycardia. Bidaud I, et al. Front Physiol, 2020. PMID 33551824, Free PMC Article
    2. Evaluation of the role of I(KACh) in atrial fibrillation using a mouse knockout model. Kovoor P, et al. J Am Coll Cardiol, 2001 Jun 15. PMID 11419900
    3. Brain localization and behavioral impact of the G-protein-gated K+ channel subunit GIRK4. Wickman K, et al. J Neurosci, 2000 Aug 1. PMID 10908597, Free PMC Article
    4. Predisposition to late-onset obesity in GIRK4 knockout mice. Perry CA, et al. Proc Natl Acad Sci U S A, 2008 Jun 10. PMID 18523006, Free PMC Article
    5. Cardiac specific ATP-sensitive K+ channel (KATP) overexpression results in embryonic lethality. Toib A, et al. J Mol Cell Cardiol, 2012 Sep. PMID 22796573, Free PMC Article

    See all (58) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that potassium inwardly-rectifying channel subfamily J member 5 (Kcnj5) is important for baseline aldosterone secretion, but its importance is sex-limited at least in the mouse.
      Title: Targeted disruption of the Kcnj5 gene in the female mouse lowers aldosterone levels.
    2. histone H4 hyperacetylation induced by Class I HDACs inhibitors promoted the expression profiles of potassium channels (Kcnj2, Kcnj3, Kcnj5, Kcnj11, and Kcnh2)
      Title: Regulation of Histone Acetylation on Expression Profiles of Potassium Channels During Cardiomyocyte Differentiation From Mouse Embryonic Stem Cells.
    3. These results provide a novel molecular mechanism for autocrine negative feedback regulation of insulin secretion.
      Title: Autocrine insulin increases plasma membrane K(ATP) channel via PI3K-VAMP2 pathway in MIN6 cells.
    4. study establishes the role of f-channels in cardiac automaticity and indicates that arrhythmia related to HCN loss-of-function may be managed by pharmacological or genetic inhibition of GIRK4 channels
      Title: Cardiac arrhythmia induced by genetic silencing of 'funny' (f) channels is rescued by GIRK4 inactivation.
    5. expressed in outer sarcolemmas and ventricular t-tubular system of mouse heart
      Title: G-protein-coupled inward rectifier potassium current contributes to ventricular repolarization.
    6. Data indicate taht m2R-RGS6-IKACh pathway sets heart rate variability independently from the autonomic input.
      Title: Essential role of the m2R-RGS6-IKACh pathway in controlling intrinsic heart rate variability.
    7. the K(ATP) channel may have an important physiological role during early cardiac development.
      Title: Cardiac specific ATP-sensitive K+ channel (KATP) overexpression results in embryonic lethality.
    8. Therefore, the lack of proper functioning of the cardio-protective K(ATP) system in the mdx cardiomyocytes may be part of the mechanism contributing to development of cardiac disease in dystrophic patients.
      Title: Dystrophin is required for the normal function of the cardio-protective K(ATP) channel in cardiomyocytes.
    9. Our present study reinforces a role for the sulfonylurea-sensitive KATP channel in cardioprotection.
      Title: Cardiomyocyte sulfonylurea receptor 2-KATP channel mediates cardioprotection and ST segment elevation.
    10. Data suggest HL-1 cells express GIRK1/4 and M2 muscarinic receptors and are a good model to study acetylcholine-activated potassium currents.
      Title: HL-1 cells express an inwardly rectifying K+ current activated via muscarinic receptors comparable to that in mouse atrial myocytes.
    Submit: New GeneRIF Correction See all GeneRIFs (13)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to G-protein activated inward rectifier potassium channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables G-protein activated inward rectifier potassium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables inward rectifier potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to inward rectifier potassium channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables inward rectifier potassium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in membrane repolarization during atrial cardiac muscle cell action potential IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in membrane repolarization during atrial cardiac muscle cell action potential ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in potassium ion import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion import across plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in potassium ion transmembrane transport NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of heart rate by cardiac conduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of heart rate by cardiac conduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of monoatomic ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of I(KACh) inward rectifier potassium channel complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in T-tubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of voltage-gated potassium channel complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    G protein-activated inward rectifier potassium channel 4
    Names
    cardiac inward rectifier
    heart KATP channel
    inward rectifier K(+) channel Kir3.4
    potassium channel, inwardly rectifying subfamily J member 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001411833.1 → NP_001398762.1  G protein-activated inward rectifier potassium channel 4 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC132114
      UniProtKB/Swiss-Prot
      P48545, P97508, Q3TPX9
      UniProtKB/TrEMBL
      Q9QYM1
      Related
      ENSMUSP00000149000.2, ENSMUST00000214223.2

    2. NM_001411834.1 → NP_001398763.1  G protein-activated inward rectifier potassium channel 4 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC132114
      UniProtKB/Swiss-Prot
      P48545, P97508, Q3TPX9
      UniProtKB/TrEMBL
      Q9QYM1

    3. NM_001411835.1 → NP_001398764.1  G protein-activated inward rectifier potassium channel 4 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC132114
      UniProtKB/Swiss-Prot
      P48545, P97508, Q3TPX9
      UniProtKB/TrEMBL
      Q9QYM1

    4. NM_001411836.1 → NP_001398765.1  G protein-activated inward rectifier potassium channel 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC132114
      UniProtKB/TrEMBL
      Q9QYM1

    5. NM_010605.6 → NP_034735.3  G protein-activated inward rectifier potassium channel 4 isoform 1

      See identical proteins and their annotated locations for NP_034735.3

      Status: VALIDATED

      Source sequence(s)
      AC132114
      Consensus CDS
      CCDS22952.1
      UniProtKB/Swiss-Prot
      P48545, P97508, Q3TPX9
      UniProtKB/TrEMBL
      Q9QYM1
      Related
      ENSMUSP00000034533.6, ENSMUST00000034533.7
      Conserved Domains (2) summary
      pfam01007
      Location:54 → 193
      IRK; Inward rectifier potassium channel
      pfam17655
      Location:200 → 371
      IRK_C; Inward rectifier potassium channel C-terminal domain

    RNA

    1. NR_157190.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC132114

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      32226002..32255640 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017313154.3 → XP_017168643.1  G protein-activated inward rectifier potassium channel 4 isoform X1

      UniProtKB/TrEMBL
      Q9QYM1
      Conserved Domains (2) summary
      pfam01007
      Location:103 → 242
      IRK; Inward rectifier potassium channel
      pfam17655
      Location:249 → 420
      IRK_C; Inward rectifier potassium channel C-terminal domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P48545.3 GenPept UniProtKB/Swiss-Prot:P48545

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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