Fermt3 fermitin family member 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fermt3provided by MGI
Official Full Name: fermitin family member 3provided by MGI
Primary source: MGI:MGI:2147790
See related: Ensembl:ENSMUSG00000024965 AllianceGenome:MGI:2147790
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Kindlin3
Summary: Enables integrin binding activity. Involved in several processes, including integrin activation; platelet aggregation; and regulation of cell-cell adhesion mediated by integrin. Located in podosome. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; immune system; and skin. Used to study leukocyte adhesion deficiency 3. Human ortholog(s) of this gene implicated in leukocyte adhesion deficiency 1 and leukocyte adhesion deficiency 3. Orthologous to human FERMT3 (FERM domain containing kindlin 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in thymus adult (RPKM 110.9), spleen adult (RPKM 102.1) and 13 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 A; 19 5.13 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (6976326..6996837, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (6998958..7019469, complement)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Immune-Related Molecules CD3G and FERMT3: Novel Biomarkers Associated with Sepsis.
Title: Immune-Related Molecules CD3G and FERMT3: Novel Biomarkers Associated with Sepsis.
Kindlin-3 maintains marginal zone B cells but confines follicular B cell activation and differentiation.
Title: Kindlin-3 maintains marginal zone B cells but confines follicular B cell activation and differentiation.
Low kindlin-3 levels in osteoclasts of kindlin-3 hypomorphic mice result in osteopetrosis due to leaky sealing zones.
Title: Low kindlin-3 levels in osteoclasts of kindlin-3 hypomorphic mice result in osteopetrosis due to leaky sealing zones.
Kindlin-3 mutation in mesenchymal stem cells results in enhanced chondrogenesis.
Title: Kindlin-3 mutation in mesenchymal stem cells results in enhanced chondrogenesis.
Autophagy promotes osteoclast podosome disassembly and cell motility athrough the interaction of kindlin3 with LC3.
Title: Autophagy promotes osteoclast podosome disassembly and cell motility athrough the interaction of kindlin3 with LC3.
Kindlin3 regulates biophysical properties and mechanics of membrane to cortex attachment.
Title: Kindlin3 regulates biophysical properties and mechanics of membrane to cortex attachment.
Kindlin-3 loss curbs chronic myeloid leukemia in mice by mobilizing leukemic stem cells from protective bone marrow niches.
Title: Kindlin-3 loss curbs chronic myeloid leukemia in mice by mobilizing leukemic stem cells from protective bone marrow niches.
Frontline Science: Kindlin-3 is essential for patrolling and phagocytosis functions of nonclassical monocytes during metastatic cancer surveillance.
Title: Frontline Science: Kindlin-3 is essential for patrolling and phagocytosis functions of nonclassical monocytes during metastatic cancer surveillance.
Kindlin-3 in platelets and myeloid cells differentially regulates deep vein thrombosis in mice.
Title: Kindlin-3 in platelets and myeloid cells differentially regulates deep vein thrombosis in mice.
The kindlin-3 not only activates and clusters integrins into podosomes but also regulates their lifetime by recruiting leupaxin, which controls PTP-PEST activity and thereby paxillin phosphorylation and downstream signaling.
Title: A kindlin-3-leupaxin-paxillin signaling pathway regulates podosome stability.

Submit: New GeneRIF Correction See all GeneRIFs (33)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation
Targeted (8) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH126713 (e-PCR)
- UniSTS:209414

NoName (e-PCR)
- UniSTS:237863

BC032204 (e-PCR), detects polymorphism
- UniSTS:498221

BC032204 (e-PCR), detects polymorphism
- UniSTS:498222

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables integrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables integrin binding	IDA Inferred from Direct Assay more info	PubMed
enables integrin binding	IPI Inferred from Physical Interaction more info	PubMed
enables lipid binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell-matrix adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in integrin activation	IBA Inferred from Biological aspect of Ancestor more info
involved_in integrin activation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in integrin activation	ISO Inferred from Sequence Orthology more info
involved_in integrin activation	ISS Inferred from Sequence or Structural Similarity more info
involved_in integrin-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in integrin-mediated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in leukocyte cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in leukocyte cell-cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in leukocyte cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in leukocyte cell-cell adhesion	ISS Inferred from Sequence or Structural Similarity more info
involved_in platelet aggregation	IBA Inferred from Biological aspect of Ancestor more info
involved_in platelet aggregation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cell-cell adhesion mediated by integrin	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell-cell adhesion mediated by integrin	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell-cell adhesion mediated by integrin	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell-cell adhesion mediated by integrin	ISS Inferred from Sequence or Structural Similarity more info
involved_in substrate adhesion-dependent cell spreading	ISO Inferred from Sequence Orthology more info
involved_in substrate adhesion-dependent cell spreading	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
is_active_in cell-substrate junction	IBA Inferred from Biological aspect of Ancestor more info
located_in podosome	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: fermitin family homolog 3

Names: unc-112-related protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001362399.1 → NP_001349328.1 fermitin family homolog 3

Status: VALIDATED

Source sequence(s)

AC120557, AC163098

Consensus CDS

CCDS29518.1

UniProtKB/Swiss-Prot

Q8K1B8

UniProtKB/TrEMBL

Q3TEE6

Conserved Domains (4) summary

smart00295
Location:221 → 301

B41; Band 4.1 homologues

cd01237
Location:350 → 474

PH_fermitin; Fermitin family pleckstrin homology (PH) domain

cd13205
Location:550 → 641

FERM_C_fermitin; FERM domain C-lobe of the Fermitin family

pfam00373
Location:490 → 555

FERM_M; FERM central domain
NM_153795.2 → NP_722490.1 fermitin family homolog 3

See identical proteins and their annotated locations for NP_722490.1

Status: VALIDATED

Source sequence(s)

AC163098, AK142912

Consensus CDS

CCDS29518.1

UniProtKB/Swiss-Prot

Q8K1B8

UniProtKB/TrEMBL

Q3TEE6

Related

ENSMUSP00000037858.9, ENSMUST00000040772.9

Conserved Domains (4) summary

smart00295
Location:221 → 301

B41; Band 4.1 homologues

cd01237
Location:350 → 474

PH_fermitin; Fermitin family pleckstrin homology (PH) domain

cd13205
Location:550 → 641

FERM_C_fermitin; FERM domain C-lobe of the Fermitin family

pfam00373
Location:490 → 555

FERM_M; FERM central domain