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    Klf6 KLF transcription factor 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 58954, updated on 9-Dec-2024

    Summary

    Official Symbol
    Klf6provided by RGD
    Official Full Name
    KLF transcription factor 6provided by RGD
    Primary source
    RGD:62389
    See related
    AllianceGenome:RGD:62389
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Zf9; CPBP; Copeb; Aa1017
    Summary
    Enables DNA-binding transcription factor activity and double-stranded DNA binding activity. Involved in several processes, including cellular response to cycloheximide; cellular response to hydrogen peroxide; and cellular response to peptide. Predicted to be located in cytosol; fibrillar center; and nucleoplasm. Human ortholog(s) of this gene implicated in prostate cancer and stomach cancer. Orthologous to human KLF6 (KLF transcription factor 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 235.0), Heart (RPKM 128.3) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Klf6 in Genome Data Viewer
    Location:
    17q12.1
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (69449483..69458478, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (64539456..64548451, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (67887939..67945052, complement)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1, pseudogene 3 Neighboring gene heat shock protein family A (Hsp70) member 8, pseudogene 5 Neighboring gene uncharacterized LOC134482870 Neighboring gene small nucleolar RNA SNORA17

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    Krueppel-like factor 6
    Names
    Kruppel-like factor 6
    core promoter element binding protein
    transcription factor Zf9

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031642.5NP_113830.2  Krueppel-like factor 6

      See identical proteins and their annotated locations for NP_113830.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/Swiss-Prot
      O35819, Q4V8M5
      UniProtKB/TrEMBL
      A0A8L2R4Q4, A6JLM9
      Conserved Domains (4) summary
      COG5048
      Location:211299
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:239258
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:234258
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:280305
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      69449483..69458478 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)