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    Adamts12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 294809, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Adamts12provided by RGD
    Official Full Name
    ADAM metallopeptidase with thrombospondin type 1 motif, 12provided by RGD
    Primary source
    RGD:1307323
    See related
    EnsemblRapid:ENSRNOG00000018865 AllianceGenome:RGD:1307323
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable metalloendopeptidase activity. Predicted to be involved in several processes, including cellular response to cytokine stimulus; negative regulation of cellular response to growth factor stimulus; and skeletal system development. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix. Orthologous to human ADAMTS12 (ADAM metallopeptidase with thrombospondin type 1 motif 12). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 144.1), Lung (RPKM 89.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Adamts12 in Genome Data Viewer
    Location:
    2q16
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (61759975..62054716)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (60032873..60327629)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (61039072..61340687)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120100741 Neighboring gene relaxin family peptide receptor 3 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene threonyl-tRNA synthetase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Epigenetic regulatory mechanism of ADAMTS12 expression in osteoarthritis. Yang S, et al. Mol Med, 2023 Jul 3. PMID 37400752, Free PMC Article
    2. Expression of ADAMTS-7 and ADAMTS-12 in the nucleus pulposus during degeneration of rat caudal intervetebral disc. Yu H, et al. J Vet Med Sci, 2012 Jan. PMID 21869572
    3. Regulated expression of ADAMTS-12 in human trophoblastic cells: a role for ADAMTS-12 in epithelial cell invasion? Beristain AG, et al. PLoS One, 2011 Apr 11. PMID 21494557, Free PMC Article
    4. The ADAMTS12 metalloproteinase exhibits anti-tumorigenic properties through modulation of the Ras-dependent ERK signalling pathway. Llamazares M, et al. J Cell Sci, 2007 Oct 15. PMID 17895370
    5. ADAMTS-12 metalloprotease is necessary for normal inflammatory response. Moncada-Pazos A, et al. J Biol Chem, 2012 Nov 16. PMID 23019333, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Epigenetic regulatory mechanism of ADAMTS12 expression in osteoarthritis.
      Title: Epigenetic regulatory mechanism of ADAMTS12 expression in osteoarthritis.
    2. ADAMTS-7 and ADAMTS-12 expression were dramatically increased during disc degeneration.
      Title: Expression of ADAMTS-7 and ADAMTS-12 in the nucleus pulposus during degeneration of rat caudal intervetebral disc.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metalloendopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell-matrix adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to BMP stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to interleukin-1 ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to tumor necrosis factor ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chondrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in collagen fibril organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in extracellular matrix organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of cellular response to hepatocyte growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cellular response to vascular endothelial growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of chondrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of hepatocyte growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ossification ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ossification involved in bone maturation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteoglycan catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteoglycan metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis involved in protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of endothelial tube morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    A disintegrin and metalloproteinase with thrombospondin motifs 12
    Names
    a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 12

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106420.4 → NP_001099890.2  A disintegrin and metalloproteinase with thrombospondin motifs 12 precursor

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      D3ZTJ3
      Related
      ENSRNOP00000025693.6, ENSRNOT00000025693.9
      Conserved Domains (7) summary
      smart00209
      Location:549 → 600
      TSP1; Thrombospondin type 1 repeats
      cd04273
      Location:250 → 457
      ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
      pfam01421
      Location:250 → 460
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:80 → 196
      Pep_M12B_propep; Reprolysin family propeptide
      pfam05986
      Location:706 → 816
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam17061
      Location:1021 → 1176
      PARM; PARM
      cl15456
      Location:519 → 680
      ADAM_CR; ADAM cysteine-rich

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      61759975..62054716
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039101948.2 → XP_038957876.1  A disintegrin and metalloproteinase with thrombospondin motifs 12 isoform X1

      Conserved Domains (7) summary
      smart00209
      Location:549 → 600
      TSP1; Thrombospondin type 1 repeats
      cd04273
      Location:250 → 457
      ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
      pfam05986
      Location:706 → 816
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam01562
      Location:53 → 197
      Pep_M12B_propep; Reprolysin family propeptide
      pfam17771
      Location:472 → 536
      ADAM_CR_2; ADAM cysteine-rich domain
      pfam19030
      Location:952 → 1000
      TSP1_ADAMTS; Thrombospondin type 1 domain
      cl15456
      Location:519 → 680
      ADAM_CR; ADAM cysteine-rich
    Nucleotide Protein Strain
    Heading Accession and Version

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