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    Aimp1 aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 114632, updated on 9-Dec-2024

    Summary

    Official Symbol
    Aimp1provided by RGD
    Official Full Name
    aminoacyl tRNA synthetase complex-interacting multifunctional protein 1provided by RGD
    Primary source
    RGD:620466
    See related
    EnsemblRapid:ENSRNOG00000011384 AllianceGenome:RGD:620466
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Emap2; Scye1
    Summary
    Predicted to enable several functions, including GTPase binding activity; cytokine activity; and protein homodimerization activity. Involved in blood vessel morphogenesis and defense response to virus. Predicted to be located in cell surface; cytosol; and extracellular space. Predicted to be part of aminoacyl-tRNA synthetase multienzyme complex. Biomarker of myocardial infarction and neurodegenerative disease. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 3. Orthologous to human AIMP1 (aminoacyl tRNA synthetase complex interacting multifunctional protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 200.0), Heart (RPKM 156.5) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Aimp1 in Genome Data Viewer
    Location:
    2q43
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (223825930..223849477, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (221151907..221175458, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (237727782..237751327, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485767 Neighboring gene uncharacterized LOC102547683 Neighboring gene GIMAP family P-loop NTPase domain containing 1 Neighboring gene TBC1 domain containing kinase Neighboring gene small nucleolar RNA SNORA17 Neighboring gene nephronectin Neighboring gene MTOR associated protein, eak-7 homolog, pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Clone Names

    • MGC112632

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase binding  
    enables cytokine activity  
    enables cytokine activity PubMed 
    enables protein homodimerization activity  
    enables tRNA binding  
    Component Evidence Code Pubs
    part_of aminoacyl-tRNA synthetase multienzyme complex  
    located_in cell surface  
    located_in cytosol  
    located_in extracellular space  

    General protein information

    Preferred Names
    aminoacyl tRNA synthase complex-interacting multifunctional protein 1
    Names
    endothelial monocyte activating polypeptide 2
    small inducible cytokine subfamily E, member 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053757.1NP_446209.1  aminoacyl tRNA synthase complex-interacting multifunctional protein 1

      See identical proteins and their annotated locations for NP_446209.1

      Status: PROVISIONAL

      Source sequence(s)
      BC098675
      UniProtKB/TrEMBL
      A0A8I5Y7U7, A0A8I6A263, A6HVT5, Q4G079
      Related
      ENSRNOP00000015213.4, ENSRNOT00000015213.8
      Conserved Domains (2) summary
      cd02799
      Location:153255
      tRNA_bind_EMAP-II_like; tRNA-binding-domain-containing EMAP2-like proteins. This family contains a diverse fraction of tRNA binding proteins, including Caenorhabditis elegans methionyl-tRNA synthetase (CeMetRS), human tyrosyl- tRNA synthetase (hTyrRS), Saccharomyces cerevisiae ...
      pfam07989
      Location:3179
      Cnn_1N; Centrosomin N-terminal motif 1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      223825930..223849477 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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